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Archives of Pharmacal Research

, Volume 28, Issue 3, pp 285–289 | Cite as

New cytotoxic sulfated saponins from the starfishCertonardoa semiregularis

  • Weihong Wang
  • Hyojin Jang
  • Jongki Hong
  • Chong-Ok Lee
  • Song-Ja Bae
  • Sook Shin
  • Jee H. Jung
Drug design

Abstract

Two new sulfated saponins designated as certonardosides P2 and l3 (1 and2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfishCertonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds1 and2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.

Key words

Starfish Certonardoa semiregularis Cytotoxicity 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Weihong Wang
    • 5
  • Hyojin Jang
    • 5
  • Jongki Hong
    • 1
    • 5
  • Chong-Ok Lee
    • 2
    • 5
  • Song-Ja Bae
    • 3
    • 5
  • Sook Shin
    • 4
    • 5
  • Jee H. Jung
    • 5
  1. 1.Basic Science InstituteSeoulKorea
  2. 2.Korea Research Institute of Chemical TechnologyDaejonKorea
  3. 3.Silla UniversityBusanKorea
  4. 4.Sahmyook UniversitySeoulKorea
  5. 5.Celloge of PharmacyPusan National UniversityBusanKorea

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