Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated fromLiriodendron tulipifera

  • Mi Kyeong Moon
  • Hyun Mi Oh
  • Byoung-Mog Kwon
  • Nam-ln Baek
  • Sung-Hoon Kim
  • Ju Sin Kim
  • Dae Keun Kim
Drug Design

Abstract

The methanolic extract of the leaves ofLiriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.

Key words

Liriodendron tulipifera Lipiferolide FPTase Cell growth inhibitory activity 

Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • Mi Kyeong Moon
    • 4
  • Hyun Mi Oh
    • 1
  • Byoung-Mog Kwon
    • 1
  • Nam-ln Baek
    • 2
  • Sung-Hoon Kim
    • 3
  • Ju Sin Kim
    • 4
  • Dae Keun Kim
    • 4
  1. 1.Korea Research Institute of Bioscience and BiotechnologyKISTTaejeonKorea
  2. 2.Graduate School of Biotechnology & Plant Metabolism Research CenterKyungHee UniversitySuwonKorea
  3. 3.Lab. of Angiogenesis and Chemoprevention, Department of Oriental PathologyCollege of Oriental Medicine, Kyunghee UniversitySeoulKorea
  4. 4.College of PharmacyWoosuk UniversitySamryeKorea

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