Archives of Pharmacal Research

, 30:1575

Attenuation of beryllium induced hepatorenal dysfunction and oxidative stress in rodents by combined effect of gallic acid and piperine

  • Jun-Quan Zhao
  • Guo-Zhen Du
  • You-Cai Xiong
  • Yi-Fu Wen
  • Monika Bhadauria
  • Satendra Kumar Nirala
Article Drug efficacy and safety

Abstract

We determined a minimum effective dose of gallic acid (3,4,5-trihydroxy benzoic acid; 50 mg/ kg, i.p.) and piperine (10 mg/kg, p.o.) through their therapeutic potential and further evaluated them individually and in combination against beryllium-induced biochemical alterations and oxidative stress consequences in female albino rats. The administration of beryllium altered blood biochemical variables by significantly depleting hemoglobin, albumin and urea, whereas it enhanced bilirubin and creatinine. The release of serum transaminase, lactate dehydroge-nase and γ-glutamyl transpeptidase was significantly greater, and was concomitant with a decrease in serum alkaline phosphatase. A significant increase in lipid peroxidation and a decrease in glutathione, Superoxide dismutase and catalase in the liver and kidney was an indication of oxidative stress due to beryllium exposure. Individual administration of gallic acid and piperine moderately reversed the altered biochemical variables, whereas the combination of these was found to completely reverse the beryllium-induced biochemical alterations and oxidative stress consequences. We concluded that gallic acid exerts a synergistic effect when administered with piperine and provides a more pronounced therapeutic potential in reducing beryllium-induced hepatorenal dysfunction and oxidative stress consequences.

Key words

Beryllium toxicity Gallic acid 3,4,5-Trihydroxy benzoic acid Piperine Biochemical alterations Hepatorenal dysfunction Oxidative stress Combined therapy 

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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • Jun-Quan Zhao
    • 4
  • Guo-Zhen Du
    • 4
  • You-Cai Xiong
    • 4
  • Yi-Fu Wen
    • 1
  • Monika Bhadauria
    • 2
  • Satendra Kumar Nirala
    • 3
  1. 1.College of Animal Science and TechnologyYunnan Agricultural UniversityKunmingPR China
  2. 2.National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhouPR China
  3. 3.Institute of Cell Biology, School of Life SciencesLanzhou UniversityLanzhouPR China
  4. 4.MOE Key Laboratory of Arid and Grassland EcologyLanzhou UniversityLanzhouPR China

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