Inhibitory effect of corynoline isolated from the aerial parts ofcorydalis incisa on the acetylcholinesterase

  • Dae Keun Kim
Research Articles Article


In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts ofCorydalis incisa (Papaver-aceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 μM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.

Key words

Corydalis incisa Papaveraceae Acetylcholinesterase inhibitor Corynoline 


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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  1. 1.College of PharmacyWoosuk UniversitySamryeKorea

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