Inhibitory effect of corynoline isolated from the aerial parts ofcorydalis incisa on the acetylcholinesterase
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In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts ofCorydalis incisa (Papaver-aceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 μM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
Key wordsCorydalis incisa Papaveraceae Acetylcholinesterase inhibitor Corynoline
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