Archives of Pharmacal Research

, Volume 19, Issue 3, pp 240–242 | Cite as

A first synthesis of isofagaridine: Topoisomerase I inhibitor

  • Won-Jea Cho
  • Miyoji Hanaoka
Rapid Communications

Key Words

Isofagaridine Benzol[c]phenanthridine Topoisomerase I II inhibitors Cerium Ammonium Nitrate 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References Cited

  1. Hanaoka, M., Kobayashi, N., Shimada, K. and Mukai, C., Chemical Transformation of Protoberberines. part 10.J. Chem. Soc. Perkin Trans. I, 677 (1987).CrossRefGoogle Scholar
  2. Hanaoka, M., Cho, W.-J., Yoshida, S. and Mukai, C., Chemical Transformation of Protoberberines. 17.,Chem. Pharm. Bull., 39, 1163–1166 (1991).Google Scholar
  3. Fang, S.-D., Wang, L.-K. and Hecht, S. M., Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum,J. Org. Chem., 58, 5025–5027 (1993).CrossRefGoogle Scholar
  4. Franck, R. W. and Gupta, R. B., Bayer-Villiger Oxidation of Napthaldehyde; Easy Access to Naphoquinones.J. Org. Chem., 50, 4632–4635 (1985).CrossRefGoogle Scholar
  5. Kobayashi, F., Yokumoto, H., Suzuki, M. and Tsubaki, M.,Chem. Abstr., 1993, 118, 219845.Google Scholar
  6. McOmie, J. F. W., Watts, M. L. and West, D. E., Demethylation of Aryl Methyl Ethers by Boron Tribromide,Tetrahedron, 24, 2289–2292 (1968).CrossRefGoogle Scholar
  7. Messmer, W. A., Tin-Wa, M., Fong, H. H. S., Bevelle, C., Farnsworth, N. R., Abraham, D. J., Trojanek, J., Fagaronine a New Tumor Inhibitor Isolated from FagaraZanthoxyloides, J. Pharm. Sci., 61, 1858–1859 (1972).PubMedCrossRefGoogle Scholar
  8. Node, M., Nishide, K., Fuji, K. and Fujita, E., Demethylation of Methyl Ethers of Alcohol and Phenol with an Aluminum Halide-Thiol System.,J. Org. Chem., 45, 4275–4277 (1980).CrossRefGoogle Scholar
  9. Orlemans, E. O. M., Lammerink, B. H. M., Van Veggel, F. C. J. M., Verboom, W., Harkema, S. and Reinhoudt, D. N., The effect of a p-Quinone Moiety on the [1.6]H-Transfer and 1,5-Electrocyclization Reactions,J. Org. Chem., 53, 2278–2287 (1988).CrossRefGoogle Scholar
  10. Reed, M. W. and Moore, H. w., Efficient Synthesis of Furochromone and Furocoumarin Natural Products by Thermal Rearrangement of 4-Furyl-4-hydroxycyclobutenone,J. Org. Chem., 53, 4166–4171 (1988).CrossRefGoogle Scholar
  11. Simeon, S., Rios, J. L., Villar, A., Pharmacological Activity of Benzophenanthridine and Phenanthridine Alkaloids,Pharmazie, 44, 593–597 (1989).PubMedGoogle Scholar
  12. Sufness, M., Douros, J., In Methods in Cancer Research, De Vita, V. T., Jr., Busch, H., (Eds.), Academic Press: New York, 1979, pp. 474.Google Scholar
  13. Tan, G. T., Miller, J. F., Kinghorn, A. D., Hughes, S. J., Pezzuto, J. M., HIV-1 and HIV-2 Reverse Transcriptases: a Comparative Study of Sensitivity to Inhibition by Selected Natural Products,Biochem. Biophys. Res. Comm., 185 370–378 (1992).PubMedCrossRefGoogle Scholar
  14. Wakamatsu, T. and Nishi, T., A Convenient Synthesis of Juglone via Neutral Salcomine Oxidation,Synth. Comm., 14, 1167–1173 (1984).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1996

Authors and Affiliations

  • Won-Jea Cho
    • 2
  • Miyoji Hanaoka
    • 1
  1. 1.Faculty of Pharmaceutical SciencesKanazawa UniversityKanazawaJapan
  2. 2.College of PharmacyChonnam National UniversityKwanjuKorea

Personalised recommendations