Archives of Pharmacal Research

, Volume 19, Issue 3, pp 228–230 | Cite as

Synthesis and antitumor activity of cannabigerol

  • Seung-Hwa Baek
  • Seok Du Han
  • Chan Nam Yook
  • Young Chae Kim
  • Jung Suk Kwak
Research Articles


Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration (IC50)=31.3l μ/mL]in vitro assay.

Key words

Cannabigerol Antitumor activity Mouse skin melanoma cell 


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References Cited

  1. Baek, S. H., Yook, C. N. and Han, D. S.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent(V). A convenient single step synthesis of cannabinoids.Bull. Kor. Chem. Soc. 16(3), 293–296 (1991).Google Scholar
  2. Baek, S. H., Srebnik, M., and Mechoulam, R.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent. An improved synthesis of cannabidiol.Tetrahedron Lett. 26(8), 1083–1086 (1985).CrossRefGoogle Scholar
  3. Baik, K. U., and Ahn, B. Z.: Cyctotoxic activities of some geranylated flavones against L 1210 cell.J. Pharm. Soc. Korea, 32(2), 125–128 (1988).Google Scholar
  4. colasanti, B. K., and Gong, H., Marihuana 87, Chesher, G.; Consroe, P.; Musty, R. Ed., Australian Government Publishing Service, Canberra, pp. 119–124 (1988).Google Scholar
  5. Carmichael, J., Degraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B., Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing.Cancer Res. 47, 936–942 (1987).PubMedGoogle Scholar
  6. Dewey, W. L.: Cannabinoid pharmacology.Pharmacol. Rev., 38, 151–178 (1986).PubMedGoogle Scholar
  7. Kleinman, S., Weitzman, S. A., Cassem, N., and Andrews, E.: Double blind trial of δ-9-tetrahydrocannabinol (THC) as an adjunct to prochlorperazine for chemotherapy-induced vomiting.Curr. Ther. Res. 34, 1014–1017 (1983).Google Scholar
  8. Kang, K. S., Ryu, S. H., and Ahn, B. Z.: Antineoplastic natural products and the analogues VI.Arch. Pharm. Res. 8, 187–190 (1985).CrossRefGoogle Scholar
  9. Mechoulam, R.: In Cannabinoids as therapeutic agents, Boca Raton, CRC Press Inc., (1986).Google Scholar
  10. Mosmann, T. J.:Rapid colorimetric assays for cellular growth and survival: application to proliferation and cytotoxicity assays.Immunol. Methods, 65, 55–63 (1983).CrossRefGoogle Scholar
  11. McCabe, M., Smith, F. P., Macdonald, J. S., and Woolley, P. V.:Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy.Invest. New Drugs. 6, 243–246 (1988).PubMedCrossRefGoogle Scholar
  12. Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., and Wadleig, H. R. G.: Recent clinical experince with dronabinol.Pharmacol. Biochem. Behav. 40, 695–700 (1991).PubMedCrossRefGoogle Scholar
  13. Sallan, S. E., Cronin, C., Zelen, M., and Zinberg, N. E.: Antiemetics in patients receiving chemotherapy for cancer: A randomized comparison of δ-9-tetrahydrocannabinol and prochlorperazine.N. Engl. J. Med. 302, 135–138 (1980).PubMedGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1996

Authors and Affiliations

  • Seung-Hwa Baek
  • Seok Du Han
    • 1
  • Chan Nam Yook
    • 2
  • Young Chae Kim
  • Jung Suk Kwak
  1. 1.Department of Chemistry and Department of Oral AnatomyWonkwang UniversityIksanKorea
  2. 2.Department of Health HygienicWonkwang Public Health Junior CollegeIksanKorea

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