Archives of Pharmacal Research

, Volume 26, Issue 6, pp 449–452 | Cite as

Antibacterial coumarins fromAngelica gigas roots

  • Sanghyun Lee
  • Dong -Sun Shin
  • Ju Sun Kim
  • Ki -Bong Oh
  • Sam Sik KangEmail author


Systematic fractionation ofAngelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity againstBacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 μg/mL, respectively.

Key words

Angelica gigas Umbelliferae Antibacterial activity Coumarin MIC 


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Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Sanghyun Lee
    • 1
  • Dong -Sun Shin
    • 1
  • Ju Sun Kim
    • 1
  • Ki -Bong Oh
    • 1
    • 2
  • Sam Sik Kang
    • 1
    Email author
  1. 1.Natural Products Research InstituteSeoul National UniversityJongno-gu, SeoulKorea
  2. 2.Graduate School of Agricultural BiotechnologySeoul National UniversitySuwonKorea

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