Neuraminidase Inhibitors fromReynoutria elliptica

  • Chu-Hyun Lee
  • Sang-ln Kim
  • Kyung-Bok Lee
  • Yung-Choon Yoo
  • Si-Young Ryu
  • Kyung-Sik Song
Research Articles Articles

Abstract

In the course of screening neuraminidase inhibitors from herbal medicines, Reynoutria elliptica exhibited high inhibitory activity. Four active compounds were isolated from the ethyl acetate soluble fraction by consecutive purification using sillica gel, Sephadex LH-20 chromatography, and recrystallization. The chemical structures of these compounds were identified as 1,3,8-trihy-droxy-6-methylanthraquinone (emodin) 1,8-dihydroxy-3-methoxy-6-methylanthraquinone (emodin 3-methyl ether; physcion), 1,3,8-trihydroxy-6-hydoxymethylanthraquinone (ω-hydroxyemodin), and 3,5,4′-trihydroxystilbene (trans-resvertrol) by spectral data including MS,1 H-, and13 C-NMR. The IC50 values of emodin, emodin 3-methyl ether, ω-hydroxyemodin, andtrans-resvertrol were 2.81, 74.07, 10.49, and 8.77 μM, respectively. They did not inhibit other glycosidase such as glucosidase, mannosidase, and galactosidase, indicating that they were relatively specific inhibitors of neuraminidase.

Key words

Neuraminidase inhibitor Influenza Emodin Emodin 3-methyl ether Physcion ω-Hydroxy emodin trans-Resveratrol Reynoutria elliptica 

Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Chu-Hyun Lee
    • 1
  • Sang-ln Kim
    • 1
  • Kyung-Bok Lee
    • 2
  • Yung-Choon Yoo
    • 2
  • Si-Young Ryu
    • 3
  • Kyung-Sik Song
    • 1
  1. 1.Division of Applied Biology & Chemistry, College of Agriculture & Life SciencesKyungpook National UniversitySankyuk-DongKorea
  2. 2.College of MedicineKonyang UniversityNonsan, ChoongnamKorea
  3. 3.Korea Research Institute of Chemical TechnologyDaejonYusung-GuKorea

Personalised recommendations