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Archives of Pharmacal Research

, Volume 26, Issue 9, pp 727–730 | Cite as

Anti-tumor activities of decursinol angelate and decursin fromAngelica gigas

  • Sanghyun Lee
  • Yeon Sil Lee
  • Sang Hoon Jung
  • Kuk Hyun Shin
  • Bak-Kwang Kim
  • Sam Sik Kang
Article

Abstract

Thein vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots ofAngelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) fromA. gigas have anti-tumor activities.

Key words

Angelica gigas Umbelliferae Anti-tumor activity Decursinol angelate Decursin 

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Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Sanghyun Lee
    • 1
    • 2
  • Yeon Sil Lee
    • 1
  • Sang Hoon Jung
    • 1
  • Kuk Hyun Shin
    • 1
  • Bak-Kwang Kim
    • 2
  • Sam Sik Kang
    • 1
    • 2
  1. 1.Natural Products Research InstituteSeoul National UniversityJongno-gu, SeoulKorea
  2. 2.College of PharmacySeoul National UniversitySeoulKorea

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