Anti-tumor activities of decursinol angelate and decursin fromAngelica gigas
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Thein vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots ofAngelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) fromA. gigas have anti-tumor activities.
Key wordsAngelica gigas Umbelliferae Anti-tumor activity Decursinol angelate Decursin
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- Chi, H.-J., and Kim, H. S., Studies on the essential oils of plants ofAngelica genus in Korea (I). Essential oils ofAngelicae gigantis radix.Kor. J. Pharmacogn., 19, 239–247 (1988).Google Scholar
- Chi, H.-J., Studies on the components of Umbelliferous plants in Korea (IV).Yakhak Hoeji, 13, 47–50 (1969).Google Scholar
- Han, D. S., Pharmacognosy, 4th ed., Dongmyongsa Press, Seoul, Korea, pp. 201–202 (1992).Google Scholar
- Kim, H.-S., Park, J.-S., Park, H.-J., and Chi, H.-J., A study of the effects of the root components ofAngelica gigas Nakai on voluntary activity in mice.Kor. J. Pharmacogn., 11, 11–14 (1980).Google Scholar
- Lee, S., Kang, S. S., and Shin, K. H., Coumarins and a pyrimidine fromAngelica gigas roots.Nat. Prod. Sci., 8, 58–61 (2002).Google Scholar
- Pachaly, P., Treitner, A., and Sin, K. S., Neue Cumaringlykoside ausAngelica gigas.Pharmazie, 51, 57–61 (1996).Google Scholar
- Ryu, K. S., Hong, N. D., Kim, N. J., and Kong, Y. Y., Studies on the coumarin constituents of the root ofAngelica gigas Nakai. Isolation of decursinol angelate and assay of decursin angelate and decursin.Kor. J. Pharmacogn., 21, 64–68 (1990).Google Scholar
- Shin, K. H., Han, J. M., and Lee, I. R., Effect of the constituents ofAngelicae gigantis radix on hepatic drug metabolizing enzymes.Kor. J. Pharmacogn., 27, 323–327 (1996).Google Scholar
- Yook, C. S., Coloured medicinal plants of Korea. Academy Book, Seoul, Korea, p. 390 (1990).Google Scholar