Inhibitory effects of luteolin isolated fromixeris sonchifolia hance on the proliferation of hepg2 human hepatocellular carcinoma cells

  • Yee Su Bog
  • Lee Jung Hwa
  • Chung Hae Young
  • Im Kwang Sik
  • Bae Song Ja
  • Choi Jae Soo
  • Kim Nam DeukEmail author
Research Articles Articles


We investigated the anti-proliferative effects of luteolin and apigenin, isolated fromIxeris sonchifolia Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cycle arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting data demonstrated that the down-regulated expression of CDK4 was correlated to the increase of p53 and CDK inhibitor p2-1WAF1/cIp1 protein. These data suggest that luteolin may have potential as an anti-cancer agent.

Key words

Luteolin Apigenin Ixeris sonchifolia H. HepG2 cells Cell cycle arrest 


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Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Yee Su Bog
    • 1
  • Lee Jung Hwa
    • 1
  • Chung Hae Young
    • 1
  • Im Kwang Sik
    • 1
  • Bae Song Ja
    • 2
  • Choi Jae Soo
    • 3
  • Kim Nam Deuk
    • 1
    Email author
  1. 1.Department of PharmacyPusan National UniversityBusan
  2. 2.Department of Food and NutritionSilla UniversityBusan
  3. 3.Faculty of Food Science and BiotechnologyPukyong National UniversityBusanKorea

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