Archives of Pharmacal Research

, Volume 25, Issue 4, pp 475–479 | Cite as

Suppression of phorbol ester-induced nf-κB activation by capsaicin in cultured human promyelocytic leukemia cells

  • Seong-Su Han
  • Young-Sam Keum
  • Kyung-Soo Chun
  • Young-Joon SurhEmail author
Research Articles Articles


Capsaicin, a major pungent constituent of red pepper (Capsicum annuum L.) possesses a vast variety of pharmacologic and physiologic activities. Despite its irritant properties, the compound exerts anti-inflammatory and anti-nociceptive effects. Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-κB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin. In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-κB through inhibition of IκBα degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells. Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-κB DNA binding. Likewise, TPA-induced activation of AP-1 was mitigated by capsaicin treatment.

Key words

Activator protein-1 (AP-1) Capsaicin HL-60 cells NF-κB TPA 


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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Seong-Su Han
    • 1
  • Young-Sam Keum
    • 1
  • Kyung-Soo Chun
    • 1
  • Young-Joon Surh
    • 1
    Email author
  1. 1.Research Institute of Pharmaceutical Sciences, College of PharmacySeoul National UniversitySeoulKorea

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