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Archives of Pharmacal Research

, Volume 23, Issue 5, pp 482–487 | Cite as

Antitumor activity ofBifidobacterium spp. isolated from a healthy Korean

  • Young -Kyung Rhee
  • Eun -Ah Bae
  • Suk -Young Kim
  • Myung Joo Han
  • Eung -Chil Choi
  • Dong -Hyun KimEmail author
Research Articles Pharmacology, Toxicology & Pharmaceutics

Abstract

The antitumor activity ofBifidobacterium breve K-110, and K-111, andB. infantis K-525 was investigated. TheseBifidobacterial cells and their cell wall preparations (WPG) significantly increased the survival rate of mice who had been intraperitoneally implanted with sarcoma 180 cells. Solid tumor growth was inhibited even when the sarcoma 180 cells were implanted into the groins of the mice. However, theBifidobacterial cells did not showin vitro cytotoxicity against tumor cell lines. Cell kinetic studies revealed that these WPGs induced neutrophils, which were followed by macrophages, at the site of peritoneal injection. The WPGs directly activated these cells to inhibit the growth of tumor cells inin vitro assays. Our results suggest thatBifidobacterial WPGs induced and activate nonspecific phagocytes,in situ to reject growing tumor cells in the mouse peritoneal cavity.

Key words

Bifidobacteria Antitumor activity Cell wall Cytotoxitiy 

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Young -Kyung Rhee
    • 1
  • Eun -Ah Bae
    • 1
  • Suk -Young Kim
    • 2
  • Myung Joo Han
    • 1
  • Eung -Chil Choi
    • 3
  • Dong -Hyun Kim
    • 2
    Email author
  1. 1.Department of Food and NutritionKyung Hee UniversitySeoulKorea
  2. 2.College of PharmacyKyung Hee UniversitySeoulKorea
  3. 3.College of PharmacySeoul National UniversitySeoulKorea

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