Antitumor activity ofBifidobacterium spp. isolated from a healthy Korean
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The antitumor activity ofBifidobacterium breve K-110, and K-111, andB. infantis K-525 was investigated. TheseBifidobacterial cells and their cell wall preparations (WPG) significantly increased the survival rate of mice who had been intraperitoneally implanted with sarcoma 180 cells. Solid tumor growth was inhibited even when the sarcoma 180 cells were implanted into the groins of the mice. However, theBifidobacterial cells did not showin vitro cytotoxicity against tumor cell lines. Cell kinetic studies revealed that these WPGs induced neutrophils, which were followed by macrophages, at the site of peritoneal injection. The WPGs directly activated these cells to inhibit the growth of tumor cells inin vitro assays. Our results suggest thatBifidobacterial WPGs induced and activate nonspecific phagocytes,in situ to reject growing tumor cells in the mouse peritoneal cavity.
Key wordsBifidobacteria Antitumor activity Cell wall Cytotoxitiy
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