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Archives of Pharmacal Research

, Volume 25, Issue 2, pp 151–153 | Cite as

Pseudoguaianolides isolated from inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

  • Hyun-Tai Lee
  • Seung-Won Yang
  • Kyeong Ho Kim
  • Eun-Kyoung Seo
  • Woongchon Mar
Research Articles Medicinal Chemistry & Natural Products

Abstract

Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers ofInula britannica var. chinensis. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L-N6-(1-iminoethyl)lysine (IC50 3.49 üM). 2,3-Dihydroaroma-ticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 üM, respectively.

Key words

Inula britannica var. chinensis Bigelovin 2,3-Dihydroaromaticin Ergolide iNOS inhibitor 

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Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Hyun-Tai Lee
    • 1
  • Seung-Won Yang
    • 2
  • Kyeong Ho Kim
    • 3
  • Eun-Kyoung Seo
    • 1
  • Woongchon Mar
    • 2
  1. 1.Natural Products Chemistry LaboratoryCollege of Pharmacy, Ewha Womans UniversitySeoulKorea
  2. 2.College of Pharmacy & Natural Products Research Institute, Seoul National UniversitySeoulKorea
  3. 3.College of PharmacyKangwon National UniversityChunchonKorea

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