Advertisement

Archives of Pharmacal Research

, Volume 22, Issue 2, pp 225–227 | Cite as

A new cytotoxic acyclic diterpene fromCarpesium divaricatum

  • Ok Pyo Zee
  • Dae Keun Kim
  • Sang Un Choi
  • Chong Ock Lee
  • Kang Ro Lee
Research Articles Natural Products

Abstract

A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxygeranylgeraniol (2) were isolated from the aerial parts ofCarpesium divaricatum. The structure of1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds1 and2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 values ranging from 4.3–10.2 μg/ml and 4.1–8.3 μg/ml, respectively.

Key words

Carpesium divaricatum Acyclic diterpene Cytotoxicity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References cited

  1. Breitmaier, E. and Voeter, W., In: Carbon-13 NMR-Spectroscopy. High Resolution Methods and Applications in Organic Chemistry and Biochemistry, VCH Publishers, New York, pp. 327–337, 1990.Google Scholar
  2. Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H. and Parks, W. P.,in vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors.J. Natl. Cancer Inst. 51, 1417–1421 (1973).PubMedGoogle Scholar
  3. Kim, D. K., Lee, K. R. and Zee, O. P., Sesquiterpene lactones fromCarpesium divaricatum.Phytochemistry 46, 1245–1247 (1997a).CrossRefGoogle Scholar
  4. Kim, D. K., Baek, N.-I., Choi, S. H., Lee, K. R. and Zee, O. P., Four new cytotoxic germacranolides fromCarpesium divaricatum.J. Nat. Prod. 60, 1199–1202 (1997b).PubMedCrossRefGoogle Scholar
  5. Robert, V., Bernard, B., Christian, F., Louis, C. and Adrien, C., An acyclic diterpene from the brown algaBifurcaria bifurcata.Phytochemistry 25, 751–752 (1986).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Ok Pyo Zee
    • 3
  • Dae Keun Kim
    • 1
  • Sang Un Choi
    • 2
  • Chong Ock Lee
    • 2
  • Kang Ro Lee
    • 3
  1. 1.Natural Products Laboratory, College of PharmacyWoosuk UniversityCheonjuKorea
  2. 2.Pharmaceutical Screening TeamKorea Research Institute of Chemical TechnologyTaejeonKorea
  3. 3.Natural Products Laboratory, College of PharmacySungKyunKwan UniversitySuwonKorea

Personalised recommendations