Abstract
A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxygeranylgeraniol (2) were isolated from the aerial parts ofCarpesium divaricatum. The structure of1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds1 and2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 values ranging from 4.3–10.2 μg/ml and 4.1–8.3 μg/ml, respectively.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References cited
Breitmaier, E. and Voeter, W., In: Carbon-13 NMR-Spectroscopy. High Resolution Methods and Applications in Organic Chemistry and Biochemistry, VCH Publishers, New York, pp. 327–337, 1990.
Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H. and Parks, W. P.,in vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors.J. Natl. Cancer Inst. 51, 1417–1421 (1973).
Kim, D. K., Lee, K. R. and Zee, O. P., Sesquiterpene lactones fromCarpesium divaricatum.Phytochemistry 46, 1245–1247 (1997a).
Kim, D. K., Baek, N.-I., Choi, S. H., Lee, K. R. and Zee, O. P., Four new cytotoxic germacranolides fromCarpesium divaricatum.J. Nat. Prod. 60, 1199–1202 (1997b).
Robert, V., Bernard, B., Christian, F., Louis, C. and Adrien, C., An acyclic diterpene from the brown algaBifurcaria bifurcata.Phytochemistry 25, 751–752 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zee, O.P., Kim, D.K., Choi, S.U. et al. A new cytotoxic acyclic diterpene fromCarpesium divaricatum . Arch Pharm Res 22, 225–227 (1999). https://doi.org/10.1007/BF02976551
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02976551