A new cytotoxic acyclic diterpene fromCarpesium divaricatum
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A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxygeranylgeraniol (2) were isolated from the aerial parts ofCarpesium divaricatum. The structure of1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds1 and2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 values ranging from 4.3–10.2 μg/ml and 4.1–8.3 μg/ml, respectively.
Key wordsCarpesium divaricatum Acyclic diterpene Cytotoxicity
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