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Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines

  • Chung-Kyu Ryu
  • Hye-Young Kang
  • Yu-Jin Yi
  • Chong-Ock Lee
Research Articles Medicinal Chemistry & Natural Products

Abstract

6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested forin vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones4a and5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds4f and4i showed inhibitory activities for the CDK4.

Key words

6-Arylamino-7-halo-5,8-quinolinediones Cytotoxicity Human tumor cell lines CDK4 

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Chung-Kyu Ryu
    • 1
  • Hye-Young Kang
    • 1
  • Yu-Jin Yi
    • 1
  • Chong-Ock Lee
    • 2
  1. 1.College of PharmacyEwha Womans UniversitySeoulKorea
  2. 2.Korea Research Institute of Chemical TechnologyTaejonKorea

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