Isolation of handelin fromChrysanthemum boreale

  • Sam Sik Kang
  • Ju Sun Kim
  • Kun Ho Son
  • Chong Ock Lee
  • Young Hee Kim
Research Articles


The flowers ofChrysanthemum boreale afforded handelin, a unique guaianolide dimer and a mixture ofn-hydrocarbons andn-hydrocarbon alcohols in addition to β-sitosterol and β-sitosterol glucoside. Detailed analysis of the1H-and11C-NMR spectra of handelin was carried out by the application of two-dimensional1H-1H-COSY and1H-11C multiple-bond, multiplequantum sepctroscopic correlation techniques. Handelin was inactive in thein vitro anti-tumor activity.

Key words

Chrysanthemum boreale Compositae Guaianolide dimer Handelin NMR assignment Anti-tumor activity 

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Copyright information

© The Pharmaceutical Society of Korea 1996

Authors and Affiliations

  • Sam Sik Kang
    • 1
  • Ju Sun Kim
    • 1
  • Kun Ho Son
    • 2
  • Chong Ock Lee
    • 3
  • Young Hee Kim
    • 4
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea
  2. 2.Department of Food and NutritionAndong National UniversityAndongKorea
  3. 3.Pharmaceutical Screening Lab.Korea Research Institute of Chemical TechnologyTaejeonKorea
  4. 4.College of Natural SciencesSangji UniversityWonjuKorea

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