Anticonvulsant compounds from the wood ofCaesalpinia sappan L.

  • Nam-In Baek
  • Seong Gyu Jeon
  • Eun-Mi Ahn
  • Jae-Taek Hahn
  • Jae Hoon Bahn
  • Joong Sik Jang
  • Sung-Woo Cho
  • Jin Kyu Park
  • Soo Young Choi
Research Articles Medicinal Chemistry & Natural Products

DOI: 10.1007/BF02975445

Cite this article as:
Baek, NI., Jeon, S.G., Ahn, EM. et al. Arch Pharm Res (2000) 23: 344. doi:10.1007/BF02975445

Abstract

80% Aqueous MeOH extracts from the wood ofCaesalpinia sappan, which showed remarkable anticonvulsant activity, were fractionated using EtOAc,n-BuOH, and H2O. Among them, the EtOAc fraction significantly inhibited the activities of two GABA degradative enzymes, succinic semialdehyde dehydrogenase (SSADH) and succinic semialdehyde reductase (SSAR). Repeated column chromatographies for the fraction guided by activity test led to the isolation of the two active principal components. Their chemical structures were determined to be sappanchalcone and brazilin based on spectral data. The pure compounds, sappanchalcone (1) and brazilin (2), inactivated the SSAR activities in a dose dependent manner, whereas SSADH was inhibited partially by sappanchalcone and not by brazilin.

Key words

Caesalpinia sappan Anticonvulsant Brazilin Sappanchalcone Succinic semialdehyde reductase Succinic semialdehyde dehydrogenase 

Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Nam-In Baek
    • 1
  • Seong Gyu Jeon
    • 2
  • Eun-Mi Ahn
    • 1
  • Jae-Taek Hahn
    • 1
  • Jae Hoon Bahn
    • 2
  • Joong Sik Jang
    • 2
  • Sung-Woo Cho
    • 3
  • Jin Kyu Park
    • 4
  • Soo Young Choi
    • 2
  1. 1.Department of Life SciencesKyunghee UniversitySuwonKorea
  2. 2.Department of Genetic Engineering, Division of Life SciencesHallym UniversityChunchonKorea
  3. 3.Department of BiochemistryUniversity of Ulsan College of MedicineSeoulKorea
  4. 4.Korea Ginseng & Tobacco Research InstituteTaejeonKorea
  5. 5.Department of Life SciencesKyung Hee UniversityYongin-Si, Kyunggi-DoKorea

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