Archives of Pharmacal Research

, Volume 21, Issue 5, pp 618–620 | Cite as

Thymol derivatives fromCarpesium divaricatum

  • Ok Pyo Zee
  • Dae Keun Kim
  • Kang Ro Lee


Four thymol derivatives, 2,5-dimethoxythymol (1), 2-methoxythymol isobutyrate (2), 10-isobutyloxy-8,9-epoxythymolisobutyrate (3) and 10-(2-methylbutyloxy)-8,9-epoxythymolisobutyrate (4) were isolated from the aerial parts ofCarpesium divaricatum. The structures were elucidated by high field 1D and 2D NMR techniques.

Key words

Carpesium divaricatum 2,5-Dimethoxythymol 2-Methoxythymol isobutyrate 10-Isobutyloxy-8,9-epoxythymolisobutyrate 10-(2-Methylbutyloxy)-8,9-epoxythymolisobutyrate 


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References Cited

  1. Bohlmann, F., Niedballa, U. and Schulz, J., Ueber einige Thymol derivate ausGaillardia- und Helenium-Arten.Chem. Ber. 102, 864–871 (1969).CrossRefGoogle Scholar
  2. Bohlmann, F., Zdero, C., Jakupovic, J., Robinson, H. and King, R. M., Eriolanolides, eudesmanolides and a rearranged sesquiterpene fromEriophyllum species.Phytochemistry, 20, 2239–2244 (1981).CrossRefGoogle Scholar
  3. Kim, D. K., Lee, K. R. and Zee, O. P., Sesquiterpene lactones fromCarpesium divaricatum.Phytochemistry 46, 1245–1247 (1997).CrossRefGoogle Scholar
  4. Kim, D. K., Baek, N. I., Choi, S. H., Lee, K. R. and Zee, O. P., Four new cytotoxic germacranolides fromCarpesium divaricatum.J. Nat. Prod. 60, 1199–1202 (1997).PubMedCrossRefGoogle Scholar
  5. Lee, T. B.,Illustrated Flora of Korea. Hayngmoonsa, Seoul, p. 731, 1989.Google Scholar
  6. Mohamed, M., Abdel-Aziz, D. and Saud, M., A new thymol derivative fromPulicaria undulata.Chem. Pharm. Bull., 34, 378–379 (1986).Google Scholar
  7. Schulte, K. E., Reisch, J. and Ruecker, G., Einige neue Inhaltstoffe der Wurzel vonArnica montana.Arch. Pharm. 296, 273–281 (1963).PubMedCrossRefGoogle Scholar
  8. Yook, C. S.,Medicinal Plants of Korea. Jin Myeong Publishing Co., Seoul, p. 392, 1981.Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Ok Pyo Zee
    • 1
  • Dae Keun Kim
    • 2
  • Kang Ro Lee
    • 1
  1. 1.Natural Products Laboratory, College of PharmacySung Kyun Kwan UniversitySuwonKorea
  2. 2.Department of Natural Products Chemistry, College of PharmacyWoosuk UniversitySamryeKorea

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