Archives of Pharmacal Research

, Volume 20, Issue 6, pp 656–658

Effects ofEurycoma longifolia Jack on sexual behaviour of male rats

  • Hool Hoon Ang
  • Meng Kwoon Sim


The effects ofEurycoma longifolia Jack were studied on the sexual behaviour of male rats. Sexually normal male rats were treated twice daily with 500 mg kg−1 of different fractions ofE. longifolia Jack for 10 days prior to test and were then observed for their copulatory behaviour with a receptive female in a copulation cage. Results showed that was a significant increase (p<0.05) in EL-1, EL-2, EL-3 but significant decrease (p<0.05) in both PEI-1 and PEI-2 in treated male rats as compared to the control male rats indicating thatE. longifolia Jack increased the sexual performance of the treated male rats by extending the duration of coitus and decreasing the refractory period between the different series of copulation. Hence, this preliminary work supports the folk use of this plant as having aphrodisiac property.

Key words

Eurycoma longifolia Jack Simaroubaceace Sexual behaviour Mounting Intromission Ejaculation 


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References Cited

  1. Ang, H. H., Chan, K. L. and Mak, J. W.,In vitro antimalarial activity of quassinoids fromEurycoma longifolia against Malaysian chloroquine-resistantPlasmodium falciparum isolates.Planta Med., 61, 177–178 (1995).PubMedCrossRefGoogle Scholar
  2. Ang, H. H., Chan, K. L. and Mak, J. W., Effect of 7-day daily replacement of culture medium containingEurycoma longifolia Jack constituents on the MalaysianPlasmodium falciparum isolates.J. Ethnopharmacol., 49, 171–175 (1995a).PubMedCrossRefGoogle Scholar
  3. Beach, E. A. and Whalen, R. E., Effect of ejaculation on sexual behaviour in the male rat.J. Comp. Physiol. Psychol., 52, 249–252 (1959).PubMedCrossRefGoogle Scholar
  4. Chan, K. L., O’Neill, M. J., Phillipson, J. D. and Warhurst, D. C., Plants as sources of antimalarial drugs. Part 3.Eurycoma longifolia Jack.Planta Med., 52, 105–107 (1986).PubMedCrossRefGoogle Scholar
  5. Chan, K. L., Lee, S. P., Sam, T. W. and Han, B. H., A quassinoid glycoside from the roots ofEurycoma longifolia.Phytochem., 28, 2857–2859 (1989).CrossRefGoogle Scholar
  6. Chan, K. L., Lee S. P. and Yuen, K. H., Antipyretic Activity of Quassinoids fromEurycoma longifolia Jack. Paper presented at the 11th Chemical Seminar on Natural Products, UNIMAS, Sarawak, Malaysia, proceedings pp. 197–204, 25–28 June, 1995.Google Scholar
  7. Ferrari, F., Baggio, G. and Mangiafico, V., The dopamine autoreceptor agonist B-HT 920 markedly stimulates sexual behaviour in male rats.Experientia, 41, 636–638 (1985).PubMedCrossRefGoogle Scholar
  8. Gimlette, J. D. and Thomson, J. W. (eds.).A Dictionary of Malayan Medicine, Oxford University Press, Kuala Lumpur, pp. 183, 1977.Google Scholar
  9. Itokawa, H., Kishi, E., Morita, H. and Takeya, K., Cytotoxic Quassinoids and Tirucallane-Type Triterpenes from the Woods ofEurycoma longifolia.Chem. Pharm. Bull., 40, 1053–1055 (1992).Google Scholar
  10. Itokawa, H., Oin, X. R., Morita, H., Takeya, K. and Iitaka, Y., Novel Quassinoids fromEurycoma longifolia.Chem. Pharm. Bull., 41, 403–405 (1993).Google Scholar
  11. Kardono, L.B.S., Angerhofer, C. K., Tsauri, S., Padmawinata, K., Pezzuto, J. M. and Kinghorn, D., Cytotoxic and antimalarial constituents of the roots ofEurycoma longifolia.J. Nat. Prod., 54, 1360–1367 (1991).PubMedCrossRefGoogle Scholar
  12. Mendelson, S. D. and Gorzalka, B. B., An Improved Chamber for the Observation and Analysis of the Sexual Behavior of the Female Rat.Physiol. Behav., 39, 67–71 (1987).PubMedCrossRefGoogle Scholar
  13. Meyerson, B. J. and Lindstrom, L., In ‘Hormonal Steriods’, V.H.T. James, L. Martini (eds.). Excerpta Medical International Congress, serial no. 219, 1971.Google Scholar
  14. Meyerson, B. J. and Lindstrom, L., Sexual motivation in the female rat.Act. Physiol. Scand. Suppl., 389, 1–80 (1973).Google Scholar
  15. Morita, H., Kishi, E., Takeya, K., Itokawa, H. and Iitaka, Y., New Quassinoids from the roots ofEurycoma longifolia.Chem. Lett., 5, 749–752 (1990).CrossRefGoogle Scholar
  16. Morita, H., Kishi, E., Takeya, K., Itokawa, H. and Iitaka, Y., Squalene derivatives fromEurycoma longifolia.Phytochem., 34, 756–771 (1993).CrossRefGoogle Scholar
  17. Sachs, B. D. and Barfield, R. J., Temporal patterning of sexual behaviour in the male rat.J. Comp. Physiol. Psychol., 73, 359–364 (1970).PubMedCrossRefGoogle Scholar
  18. Schefler, W. C.,Statistics for Health Professionals, Addison-Wesley Publishing Company, Inc., Reading, Massachusetts, pp. 251–254, 1984.Google Scholar
  19. Tada, H., Yasuda, F., Otani, K., Doteuchi, M., Ishihara, Y. and Shiro, M., New antiulcer quassinoids fromEurycoma longifolia.Eur. J. Med. Chem., 26, 345–349 (1991).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1997

Authors and Affiliations

  • Hool Hoon Ang
    • 1
  • Meng Kwoon Sim
    • 2
  1. 1.School of Pharmaceutical SciencesUniversity of Science MalaysiaMinden, PenangMalaysia
  2. 2.Department of Pharmacology, Faculty of MedicineNational University of SingaporeKent RidgeSingapore

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