Archives of Pharmacal Research

, Volume 24, Issue 5, pp 437–440

Effects ofEurycoma longifolia Jack on laevator ani muscle in both uncastrated and Testosterone-Stimulated castrated intact male rats

Research Article Medicinal Chemistry & Natural Products

Abstract

It has been reported thatEurycoma longifolia Jack commonly known as Tongkat Ali has gained notoreity as a symbol of man’s ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities. As such, the effects of 200, 400 and 800 mg/kg of butanol, methanol, water and chloroform fractions ofE. longifolia Jack were studied on the laevator ani muscle in both uncastrated and testosteronestimulated castrated intact male rats after dosing them for 12 consecutive weeks. Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions ofE. longifolia Jack significantly increased (p<0.05) the leavator ani muscle to 58.56 ±1.22, 58.23 ±0.31, 60.21 ±0.86 and 62.35 ± 0.98 mg/100g body weight, respectively, when compared with the control (untreated) in the uncastrated intact male rats and 49.23 ± 0.82, 52.23 ±0.36, 50.21 ±0.66 and 52.35 ±0.58 mg/100g body weight, respectively, when compared to control (untreated) in the testosterone-stimulated castrated intact male rats. Hence, the proandrogenic effect as shown by this study further supported the traditional use of this plant as an aphrodisiac.

Key words

Eurycoma longifolia Jack Laevator ani muscle Uucastrated Testosterone-stimulated castrated Intact male rats Pro-androgenic 

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Copyright information

© The Pharmaceutical Society of Korea 2001

Authors and Affiliations

  1. 1.School of Pharmaceutical SciencesUniversity Science Malaysia, MindenPenangMalaysia

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