Archives of Pharmacal Research

, Volume 21, Issue 4, pp 478–480

Studies of structure activity relationship of flavonoids for the anti-allergic actions

  • Ho Cheong
  • Shi-Yong Ryu
  • Min-Ho Oak
  • Seung-Hoon Cheon
  • Gyurng-Soo Yoo
  • Kyeong-Man Kim
Notes

Abstract

The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 μM.

Key words

Allergy Flavonoids Degranulation Hexosaminidase 

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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Ho Cheong
    • 1
  • Shi-Yong Ryu
    • 2
  • Min-Ho Oak
    • 1
  • Seung-Hoon Cheon
    • 1
  • Gyurng-Soo Yoo
    • 1
  • Kyeong-Man Kim
    • 1
  1. 1.College of PharmacyChonnam National UniversityKwang-JuKorea
  2. 2.Korea Institute of Chemical TechnologyTaejeonKorea

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