Amentoflavone, a plant biflavone: A new potential anti-inflammatory agent

  • Hee Kee Kim
  • Kun Ho Son
  • Hyeun Wook Chang
  • Sam Sik Kang
  • Hyun Pyo Kim
Research Articles


Biflavonoid is one of unique classes of naturally-occurring bioflavonoids. Certain biflavonoids including amentoflavone were previously reported to have inhibitory effect on the group II phospholipase A2 activity. Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase. In this study, anti-inflammatory and analgesic activities of amentoflavone were evaluated. When amentoflavone was administered intraperitoneally, it showed a potent anti-inflammatory activity as determined by amelioration of croton-oil induced mouse ear edema. It also showed a potent anti-inflammatory activity in the rat carrageenan paw edema model (ED50=42 mg/kg) compared to the activity of prednisolone (35 mg/kg) and indomethacin (10 mg/kg). However, amentoflavone did not show a significant inhibitory activity against rat adjuvant-induced arthritis, a chronic inflammatory model. In addition, amentoflavone was found to possess a potent analgesic activity in the acetic acid writhing test (ED50=9.6 mg/kg) compared to the activity of indomethacin (3.8 mg/kg). These results suggest that amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group II phospholipase A2 and cyclooxygenase.


Amentoflavone Flavonoid Biflavonoid Anti-inflammatory activity analgesic activity Phospholipase A2 Cyclooxygenase 

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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Hee Kee Kim
    • 1
  • Kun Ho Son
    • 2
  • Hyeun Wook Chang
    • 3
  • Sam Sik Kang
    • 4
  • Hyun Pyo Kim
    • 1
  1. 1.College of PharmacyKangwon National Univ.ChunchonKorea
  2. 2.Dept. Food Nutr.Andong National Univ.AndongKorea
  3. 3.College of PharmacyYeungnam Univ.GyongsanKorea
  4. 4.Natural Products Res. Inst.Seoul National Univ.SeoulKorea

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