Isolation of isoguanosine fromCroton tiglium and its antitumor activity
- 141 Downloads
This paper describes the isolation of isoguanosine fromCroton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine has an antitumor activity against implanted S-180 ascitic tumor mice. Isoguanosine is effective at the dose of 24 mg/kg/day×5, with T/C value of 168%. Isoguanosine inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/day×12 and 48 mg/kg/day×12, with 1-T/C values of 65% and 60% respectively.
Key wordsIsoguanosine Anti-tumor activity
Unable to display preview. Download preview PDF.
- Buell, M. V. and Perkins, M. E., Cryst. guanine nucleoside.J. Biol. Chem., 72, 745–748 (1927).Google Scholar
- Kim, C. W., Moon, J. C. and Kim, J. B., Cytotoxic effects of extract (CP-2) from the mixture of Coptis andCroton tiglium L. of the various tumor cell-lines.The Korean Central Journal of Medicine, 58(3), 177–184 (1993).Google Scholar
- Kim, J, H., Lee, S. J., Han, Y. B. and Kim, J. B., Identification of active compounds fromCroton tiglium andCoptis japonica aqeous mixture (CP2) and studies of it's cytotoxicity.Kor. J. Pharmaeogn., 38(1), 31–37 (1994).Google Scholar
- Kyoichi, S., Toshitaka, M. and Sueo, M. U., Antitumor activity and hematotoxicity of a new, substituted dihydrobenzo., FK 973, in mice. Cancer Res., 48, 1168–1172 (1988).Google Scholar
- Lowry, B. A. and Brown, G. B., The utilization of purine nucleosides for nucleic acid synthesis in the rat.J. Biol. Chem.,197, 591 (1952).Google Scholar