Archives of Pharmacal Research

, 29:746 | Cite as

Antifungal effect of amentoflavone derived fromSelaginella tamariscina

  • Hyun Jun Jung
  • Woo Sang Sung
  • Soo-Hwan Yeo
  • Hyun Soo Kim
  • In-Seon Lee
  • Eun-Rhan Woo
  • Dong Gun Lee
Articles Drug Development

Abstract

Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant ofSelaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose onC. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

Key words

Biflavonoid Amentoflavone Antifungal activity Dimorphic transition 

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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  • Hyun Jun Jung
    • 1
  • Woo Sang Sung
    • 1
    • 2
  • Soo-Hwan Yeo
    • 3
  • Hyun Soo Kim
    • 3
  • In-Seon Lee
    • 3
  • Eun-Rhan Woo
    • 4
  • Dong Gun Lee
    • 1
  1. 1.Department of Microbiology, College of Natural SciencesKyungpook National UniversityDaeguKorea
  2. 2.Agro-Biotechnology Education CenterKyungpook National UniversityDaeguKorea
  3. 3.The Center for Traditional Microorganism Resources (TMR)Keimyung UniversityDaeguKorea
  4. 4.College of PharmacyChosun UniversityGwangjuKorea

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