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Archives of Pharmacal Research

, Volume 15, Issue 1, pp 95–98 | Cite as

Presence of acetylcholine-like substance(s) inSesamum indicum

  • Anwar-ul Hassan Gilani
  • Khalid Aftab
Notes

Abstract

Alcoholic extract of seeds ofSesamum indicum (SI, 1–30 mg/kg) caused hypotensive action in anesthetized rats. Heart rate was also decreased at slightly higher doses (10–30 mg/kg). Pretreatment with atropine (2 mg/kg) abolished these cardiovascular responses. In isolated spontaneously beating atria from guinea-pigs, SI caused decrease in force and rate of atrial contractions. In isolated guinea-pig ileum and rat uterus, SI (100–1000 ug/ml) produced contractile responses. All these actions of SI were abolished in the presence of atropine (1 μM). These results indicate that alcoholic extract of seeds ofSesamum indicum contains acetylcholine-like constituents(s) which explains some of the folkloric uses of plant.

Keywords

Sesamum indicum seed extract hypotensive cholinergic 

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Copyright information

© The Pharmaceutical Society of Korea 1992

Authors and Affiliations

  • Anwar-ul Hassan Gilani
    • 1
  • Khalid Aftab
    • 2
  1. 1.Department of Pharmacology Medical CollegeThe Aga Khan UniversityKarachiPakistan
  2. 2.HEJ Research Institute of ChemistryUniversity of KarachiKarachiPakistan

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