Protective effect of DA-9601, an extract ofArtemisiae Herba, against naproxen-induced gastric damage in arthritic rats

  • Tae Young Oh
  • Byong Kweon Ryu
  • Jun Il Ko
  • Byoung Ok Ahn
  • Soon Hoe Kim
  • Won Bae Kim
  • Eun Bang Lee
  • Joo Hyun Jin
  • Ki Baik Hahm
Research Articles

Abstract

Gastrointestinal irritation is the most frequent adverse effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAIDs) for the treatment of arthritic conditions. Gastroprotective effect of DA-9601, a new antiulcer agent fromArtemisiae Herba extract, against NSAID was evaluated in a rat model of arthritis that is similar in many aspects to human rheumatoid arthritis. Daily oral dosing of naproxen (30 mg/kg), one of the most commonly used NSAID, induced apparent gastric lesions as well as a significant decrease in mucosal prostaglandin E2 (PGE2) and prostaglandin F (PGF) levels. Coadministration of DA-9601 prevents naproxen-induced mucosal injury and depletion, of prostaglandins, in a dose-related manner. DA-9601 did not alter the antiinflammatory or analgesic effect of naproxen. The present results suggest that DA-9601 may be useful as a mucoprotectant against NSAIDs in clinical practice.

Key words

DA-9601 Artemisiae Herba Nonsteroidal antiinflammatory drug Prostaglandin Arthritis Naproxen 

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Copyright information

© The Pharmaceutical Society of Korea 1997

Authors and Affiliations

  • Tae Young Oh
    • 1
  • Byong Kweon Ryu
    • 1
  • Jun Il Ko
    • 1
  • Byoung Ok Ahn
    • 1
  • Soon Hoe Kim
    • 1
  • Won Bae Kim
    • 1
  • Eun Bang Lee
    • 2
  • Joo Hyun Jin
    • 3
  • Ki Baik Hahm
    • 3
  1. 1.Research LaboratoriesDong-A Pharm. Co. Ltd.KyunggidoKorea
  2. 2.Natural Products InstituteSeoul National UniversitySeoulKorea
  3. 3.Department of Gastroenterology, College of MedicineAjou UniversityKyunggidoKorea

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