Cytotoxic terpene hydroperoxides from the aerial parts ofAster spathulifolius
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Abstract
Three new sesquiterpene hydroperoxides, 1-[3-(2-hydroperoxy-3-methylbut-3-en)-4-hydroxyphenyl]ethanone (2), 7β-hydroperoxy-eudesma-11-en-4-ol (3), and 7α-hydroperoxymanool (4), together with three known compounds, germacrone (1),ent-germacra-4(15),5, 10(14)-trien-1α-ol (5) and teucdiol A (6) were isolated from the aerial parts ofAster spathulifolius (Compositae). Their structures were characterized using chemical and spectroscopic methods. The isolated compounds were tested for their cytotoxicity against five human tumor cell linesin vitro using a SRB method. The two new compounds,3 and4, showed moderate cytotoxicity against human cancer cells with ED50 values ranging from 0.24 to 13.27 μg/mL.
Key words
Aster spathulifolius Compositae Hydroperoxide CytotoxicityPreview
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