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Structure and antiinflammatory activity relationships of wogonin derivatives

  • Jinhee Jang
  • Hyun Pyo Kim
  • Haeil Park
Articles Drug Design

Abstract

A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1)via several steps. Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin. Alkylation of 5,7-phenol groups and substitution at the B ring of wogonin generally caused reduction of inhibitory activity.

Key words

Wogonin derivatives COX-2 Prostaglandin production inhibition Anti-inflammatory activity 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  1. 1.College of PharmacyKangwon National UniversityChuncheonRepublic of Korea

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