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Archives of Pharmacal Research

, Volume 28, Issue 10, pp 1156–1160 | Cite as

Iridoid glycosides isolated fromOldenlandia diffusa inhibit LDL-oxidation

  • Dong-Hyun Kim
  • Hyo-Jung Lee
  • Young-Jun Oh
  • Min-Jung Kim
  • Sung-Hoon Kim
  • Tae-Sook Jeong
  • Nam-In Baek
Articles Drug Design

Abstract

An iridoid glycoside, oldenlandoside III (5) was isolated from then-butanol fraction of methanol extracts of the aerial parts ofOldenlandia diffusa Roxb, along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-benzoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds1, 2, and7 inhibited LDL-oxidation, and showed 63.3±2.0, 62.2±1.6, and 63.8±1.5% inhibition, respectively, at a concentration of 20 μg/mL.

Key words

Oldenlandia diffusa Rubiaceae Iridoid Oldenlandoside III LDL-Oxidation inhibition 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Dong-Hyun Kim
    • 1
  • Hyo-Jung Lee
    • 2
  • Young-Jun Oh
    • 1
  • Min-Jung Kim
    • 3
  • Sung-Hoon Kim
    • 2
  • Tae-Sook Jeong
    • 3
  • Nam-In Baek
    • 4
  1. 1.Graduate School of Biotechnology & Plant Metabolism Research CenterKyung Hee UniversitySuwonKorea
  2. 2.Graduate School of East-West Medical ScienceKyung Hee UniversitySuwonKorea
  3. 3.Korea Research Institute of Bioscience and BiotechnologyDaejonKorea
  4. 4.Graduate School of BiotechnologyKyung Hee UniversitySuwonKorea

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