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Archives of Pharmacal Research

, Volume 28, Issue 10, pp 1142–1146 | Cite as

Cytotoxic sesquiterpene lactones fromSaussurea calcicola

  • Sang Zin Choi
  • Sang Un Choi
  • Kang Ro Lee
Articles Drug Design

Abstract

Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts ofSaussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8α-hydroxy-11α, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3β-hydroxy-8α-epoxymethylacriloiloxy-4(15), 10(14), 11(13)-trien-guaian-6, 12-olide (6), and kandavanolide (7). Compounds1 and2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23≈1.72 μg/mL.

Key words

Saussurea calcicola Compositae Sesquiterpene lactone Cytotoxicity 

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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  1. 1.Natural Products laboratory, College of PharmacySungkyunkwan UniversitySuwonKorea
  2. 2.Korea Research Institute of Chemical TechnologyTaejeonKorea

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