Archives of Pharmacal Research

, Volume 28, Issue 10, pp 1142–1146 | Cite as

Cytotoxic sesquiterpene lactones fromSaussurea calcicola

  • Sang Zin Choi
  • Sang Un Choi
  • Kang Ro Lee
Articles Drug Design


Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts ofSaussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8α-hydroxy-11α, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3β-hydroxy-8α-epoxymethylacriloiloxy-4(15), 10(14), 11(13)-trien-guaian-6, 12-olide (6), and kandavanolide (7). Compounds1 and2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23≈1.72 μg/mL.

Key words

Saussurea calcicola Compositae Sesquiterpene lactone Cytotoxicity 


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  1. Bensky, D. and Gamble, A., “Chinese herbal medicine (Material medica)” Eastland Press, Seattle, pp. 339–340 (1986).Google Scholar
  2. Bohlmann, F. and Gupta, R. K., Further ineupatorolide like germacranolides fromInula cuspidate.Phytochemistry, 21, 157–160 (1982).CrossRefGoogle Scholar
  3. Chhabra, B. R., Gupta, S., Jain, M., and Kalsi, P. S., Sesquiterpene lactones fromSaussurea lappa.Phytochemistry, 49, 801–804 (1998).CrossRefGoogle Scholar
  4. Cho, J. Y., Baik, K. U., Jung, J. H., and Park, M. H.,In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, fromSaussurea lappa.Eur. J. Pharm., 398, 399–407 (2000).CrossRefGoogle Scholar
  5. Dai, J., Zhao, C., Zhang, Q., Liu, Z. L., Zheng, R., and Yang, L., Taraxastane type triterpenoids fromSaussurea petrovii.Phytochemistry, 58, 1107–1111 (2001).PubMedCrossRefGoogle Scholar
  6. Fernandez, I., Garcia, B., Grancha, F. J., and Pedro, J. R., Two guaianolides fromCentaurea collina.Phytochemistry, 26, 2403–2405 (1987).CrossRefGoogle Scholar
  7. Fernandez, I., Garcia, B., Grancha, F. J., and Pedro, J. R., Sesquiterpene lactones, flavonoids and coumarins fromCentaurea collina.Phytochemistry, 28, 2405–2407 (1989).CrossRefGoogle Scholar
  8. Gonzalez, A. G., Amaro, J., Fraga, B. M., and Luis, J., 3-Oxo-6β-hydroxyolean-18-enoic acid fromOrthopterygium huancuy.Phytochemistry, 22, 1828–1830 (1983).CrossRefGoogle Scholar
  9. Ha, T. J., Jang, D. S., Lee, J. R., Lee, K. D., Hwang, S. W., Jung, H. J., Nam, S. H., Park, K. H., and Yang, M. S., Cytotoxic effects of Sesquiterpene lactones from the flowers ofHemisteptia lyrata B.Arch. Pharm. Res., 26, 925–928 (2003).PubMedCrossRefGoogle Scholar
  10. Helal, A. M., Nakamura, N., Meselhy, M. R., El-Fishawy, A. M., Hattori, M., and Mahran, G. H., Guaianolides fromCentaurea scoparia.Phytochemistry, 45, 551–554 (1997).CrossRefGoogle Scholar
  11. Kisiel, W., 8-Epidesacylcynaropicrin from Crepis capillaris.Planta Med., 49, 246–247 (1983).PubMedCrossRefGoogle Scholar
  12. Li, Y. and Jia, Z. J., Guaianolides fromSaussurea involucrate.Phytochemistry, 28, 3395–3397 (1989).CrossRefGoogle Scholar
  13. Marco, J. A., Sanz, J. F., Albiach, R., Rustaiyan, A., and Habibi, Z., Bisabolene derivatives and sesquiterpene lactones fromcousinia species.Phytochemistry, 32, 395–400 (1993).CrossRefGoogle Scholar
  14. Marco, J. A., Sanz-Cervera, J. F., Yuste, A., and Oriola, M. C., Sesquiterpene lactones and dihydroflavonols fromAndryala andUrospermum species.Phytochemistry, 36, 725–729 (1994).CrossRefGoogle Scholar
  15. Marco, J. A., Sanz-cervera, J. F., Garcia-lliso, V., Susanna, A., and Garcia-Jacas, N., Sesquiterpene lactones, lignans, and aromatic esters fromCheirolophus species.Phytochemistry, 37, 1101–1107 (1994).CrossRefGoogle Scholar
  16. Matsuda, H., Kageura, T., Inoue, Y., Morikawa, T., and Yoshikawa, M., Absolute stereostructures and syntheses of Saussureamines A, B, C, D, and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots ofSaussurea lappa.Tetrahedron, 56, 7763–7777 (2000).CrossRefGoogle Scholar
  17. Rustaiyan, A., Niknejad, A., Zdero, C., and Bohlmann, F., A guaianolide fromCentaurea behen.Phytochemistry, 20, 2427–2429 (1981).CrossRefGoogle Scholar
  18. Singhal, A. K., Chowdhury, P. K., and Sharma, R. P., Guaianolides fromTricholepis glaberrima.Phytochemistry, 21, 462–463 (1982).CrossRefGoogle Scholar
  19. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening.J. Natl. Cancer Inst., 82, 1107–1112 (1990).PubMedCrossRefGoogle Scholar
  20. Youssef, D. and Frahm, A. W.,Circular dichroism of C-7, C-6trans-fused Gualanolides ofCentaurea scoparia.Phtyochemistry, 41, 1107–1111 (1996).CrossRefGoogle Scholar
  21. Zdero, C., Bohlmann, F., and Wasshausen, D. C., Guaianolides fromBrachylaena species.Phtyochemistry, 30, 3810–3811 (1991).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  1. 1.Natural Products laboratory, College of PharmacySungkyunkwan UniversitySuwonKorea
  2. 2.Korea Research Institute of Chemical TechnologyTaejeonKorea

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