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Direct comparison between 2-dimensional and 3-dimensional PET acquisition modes for myocardial blood flow absolute quantification with O-15 water and N-13 ammonia

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Positron emission tomography scanners with retractable septa allow both 3-dimensional (3D) and 2-dimensional (2D) acquisition modes. The study aim was to directly compare 2D and 3D acquisition modes for the evaluation of absolute myocardial blood flow (MBF) over a wide range of flow values.

Methods and Results

Instrumentation was used in 4 dogs to reduce the left circumflex artery lumen by greater than 75%. During infusion of adenosine, MBF was measured with both 2D and 3D dynamic acquisition and both oxygen 15 water and nitrogen 13 ammonia. Injected activities were 333 MBq and 111 MBq for 2D acquisition and 3D acquisition, respectively. Data were reconstructed by analytic methods, and MBF was assessed by use of an 18-segment model. MBF values ranged from 0.4 to 5.8 mL · g-1 · min-1 with O–15 water and from 0.3 to 3.9 mL g-1 min-1 with N-13 ammonia. No significant differences were observed in absolute MBF values obtained with the 2 acquisition modes, regardless of the flow tracer used. Two-dimensionally and three-dimensionally derived MBF values were significantly strongly correlated by use of both O-15 water (y = 0.98x + 0.18, r = 0.87, P < .001) and N-13 ammonia (y = 0.99x + 0.09, r = 0.95, P < .001).

Conclusion

Quantification of MBF in dogs with 3D positron emission tomography provides results similar to those obtained with the 2D technique, despite a lower activity being injected.

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Authors and Affiliations

  1. Departments of Nuclear Medicine, Université Catholique de Louvain, Cliniques Universitaires St-Luc, Avenue Hippocrate, 10, 1200, Brussels, Belgium

    Véronique Roelants & Jacques Melin

  2. Departments of Cardiology, Université Catholique de Louvain, Cliniques Universitaires St-Luc, Brussels, Belgium

    Xavier Bernard, Bernhard Gerber & Jean-Louis Vanoverschelde

  3. Unité Tomographie Positrons, Université Catholique de Louvain, Louvain-la-Neuve, Belgium

    Anne Bol & Ann Coppens

Authors
  1. Véronique Roelants
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  2. Anne Bol
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  3. Xavier Bernard
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  4. Ann Coppens
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  5. Jacques Melin
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  6. Bernhard Gerber
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  7. Jean-Louis Vanoverschelde
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Correspondence to Véronique Roelants.

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Roelants, V., Bol, A., Bernard, X. et al. Direct comparison between 2-dimensional and 3-dimensional PET acquisition modes for myocardial blood flow absolute quantification with O-15 water and N-13 ammonia. J Nucl Cardiol 13, 220–224 (2006). https://doi.org/10.1007/BF02971246

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  • DOI: https://doi.org/10.1007/BF02971246

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