Acta Endoscopica

, Volume 12, Issue 2, pp 171–178 | Cite as

Gastritis, nitrosamines and gastric cancer

  • G. N. Stemmermann
  • H. Mower
Article
  • 2 Downloads

Summary

Superficial gastritis accompanies peptic ulcer, gastroenterostomy, pernicious anemia, and exposure to nitrosamines. Once established, the process may be self perpetuating, resulting in atrophy, metaplasia, dysplasia and neoplasia. This can be explained, by the process of endogenous nitrosation of amines in the inflamed gastric mucosa. Evidence is presented that supports this hypothesis. Several drugs given parenterally have been identified as mutagenic nitroso compounds in homogenates of human and canine antral mucosa. Nitrite for this process is apparently derived from the inflamed mucosa. Different amines appear to be nitrosated at different places in the antrum suggesting the presence of sitespecific enzymes that control this reactions.

Key-words

gastric cancer gastritis nitrosamines 

Gastrite, nitrosamines et cancer gastrique

Résumé

La gastrite superficielle est associée à l'ulcère, la gastroentérostomie et la gastrectomie, l'anémie pernicieuse et l'exposition aux nitrosamines. Une fois établi, le processus inflammatoire tend à l'auto-entretien, aboutissant à l'atrophie, la métaplasie intestinale, la dysplasie et le cancer. Cette séquence peut être expliquée par la formation de groupes nitrés au départ d'amines présentes dans la muqueuse gastrique inflammatoire. Des faits expérimentaux sont présentés qui appuient cette hypothèse. Certains médicaments administrés par voie parentérale ont été identifiés comme composés nitrés mutatgènes présents dans des homogénats de muqueuse antrale humaine ou canine. La formation de nitrites paraît s'effectuer directement dans la muqueuse inflammatoire. Différentes amines semblent transformables en groupes nitrés: la présence d'enzymes à sites spécifiques à différents endroits de l'antre plaide en faveur d'un contrôle endomuqueux de ces réactions.

Mots-clés

cancer gastrique gastrite nitrosamines 
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. N. Stemmermann
    • 1
  • H. Mower
    • 2
  1. 1.Japan-Hawaii Center StudyKuakini Medical CenterHonolulu(USA)
  2. 2.Department of Biochemistry and Biophysics John A. Burns School of MedicineUniversity of Hawaii(USA)

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