Journal of Biosciences

, Volume 28, Issue 3, pp 323–335 | Cite as

HIV-1 Nef control of cell signalling molecules: Multiple strategies to promote virus replication

  • Alison L. GreenwayEmail author
  • Gavan Holloway
  • Dale A. McPhee
  • Phoebe Ellis
  • Alyssa Cornall
  • Michael Lidman


HIV-1 has at its disposal numerous proteins encoded by its genome which provide the required arsenal to establish and maintain infection in its host for a considerable number of years. One of the most important and enigmatic of these proteins is Nef. The Nef protein of HIV-1 plays a fundamental role in the virus life cycle. This small protein of approximately 27 kDa is required for maximal virus replication and disease progression. The mechanisms by which it is able to act as a positive factor during virus replication is an area of intense research and although some controversy surrounds Nef much has been gauged as to how it functions. Its ability to modulate the expression of key cellular receptors important for cell activation and control signal transduction elements and events by interacting with numerous cellular kinases and signalling molecules, including members of the Src family kinases, leading to an effect on host cell function is likely to explain at least in part its role during infection and represents a finely tuned mechanism where this protein assists HIV-1 to control its host.


HIV-1 Nef pathogenesis signal transduction 

Abbreviations used


Adapter protein


cytotoxic T-lymphocytes


IL-2 receptor


p21-activated kinase 2


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Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • Alison L. Greenway
    • 1
    Email author
  • Gavan Holloway
    • 1
  • Dale A. McPhee
    • 1
  • Phoebe Ellis
    • 1
  • Alyssa Cornall
    • 1
  • Michael Lidman
    • 1
  1. 1.AIDS Cellular Biology UnitMacfarlane Burnet Institute for Medical Research and Public HealthMelbourneAustralia

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