Archives of Pharmacal Research

, Volume 29, Issue 7, pp 541–547 | Cite as

Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits ofEvodia officinalis

  • Ming-Lu Xu
  • Dong-Cheol Moon
  • Chong-Soon Lee
  • Mi-Hee Woo
  • Eung Seok Lee
  • Yurngdong Jahng
  • Hyeun-Wook Chang
  • Seung-Ho Lee
  • Jong-Keun SonEmail author
Articles Drug Design


Four alkaloids (1–4), three quinolone alkaloids (5–7), and three flavanoid glucosides (8–10) were isolated from the fruits ofEvodia officinalis Dode, and their structures were determined from chemical and spectral data. Compounds,3, 8, 9 and10 were isolated from this plant for the first time. Of these compounds,1–3 and5–7 exhibited moderate cytotoxicities against cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human hepatoblastoma (HepG-2). Compound8 showed strong inhibitory effects on DNA topoisomerases I and II (70 and 96% inhibition at a concentration of 20 μM, respectively).

Key words

Evodia officinalis DNA topoisomerases I and II inhibitors Cytotoxicity 


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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  • Ming-Lu Xu
    • 2
    • 3
  • Dong-Cheol Moon
    • 4
  • Chong-Soon Lee
    • 5
  • Mi-Hee Woo
    • 6
  • Eung Seok Lee
    • 1
  • Yurngdong Jahng
    • 1
  • Hyeun-Wook Chang
    • 1
  • Seung-Ho Lee
    • 1
  • Jong-Keun Son
    • 1
    Email author
  1. 1.College of PharmacyYeungnam UniversityGyongsanKorea
  2. 2.Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules (Yanbian University)Ministry of EducationYanjiChina
  3. 3.College of PharmacyYanbian UniversityYanjiChina
  4. 4.College of PharmacyChungbuk National UniversityCheongjuKorea
  5. 5.Department of Biochemistry, College of Natural SciencesYeungnam UniversityGyongsanKorea
  6. 6.College of PharmacyCatholic University of DaeguGyongsanKorea

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