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Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum

  • Yong Deuk Min
  • Sang Un Choi
  • Kang Ro LeeEmail author
Articles Drug Design

Abstract

Chromatographic separation of the MeOH extract from the stems and rhizomes ofSinomemium acutum led to the isolation of nine alkaloids and a lignan. Their structures were determined to be dauriporphine (1), bianfugecine (2), dauriporphinoline (3), menisporphine (4), (−)-syringaresinol (5), N-feruloyltyramine (6), acutumine (7), dauricumine (8), sinomenine (9), and magnoflorine (10) by spectroscopic means. These compounds were examined for their P-gp mediated MDR reversal activity in human cancer cells. Compound1 showed the most potent P-gp MDR inhibition activity with an ED50 value 0.03 μg/mL and 0.00010 μg/mL in the MES-SA/DX5 and HCT15 cells, respectively.

Key words

Sinomenium acutum Menispermaceae MDR Aporphine alkaloid Lignan 

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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  1. 1.Natural Products Laboratory, College of PharmacySungkyunkwan UniversitySuwonKorea
  2. 2.Korea Research Institute of Chemical TechnologyDaejeonKorea

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