Breast Cancer

, Volume 10, Issue 4, pp 320–329 | Cite as

A comparison of mr imaging, galactography and ultrasonography in patients with nipple discharge

  • Hiroshi Nakahara
  • Kiyoshi Namba
  • Ryoji Watanabe
  • Hidemi Furusawa
  • Takafumi Matsu
  • Futoshi Akiyama
  • Goi Sakamoto
  • Snozo Tamura
Original Article

Abstract

Background

The aim of this study is to assess the usefulness of three-dimensional contrastenhanced magnetic resonance (MR) imaging, compared with galactography and ultrasonography (US).

Methods

Fifty-five patients with bloody nipple discharge were investigated retrospectively. All patients were examined by galactography, ultrasonography and MR imaging. These three sets of findings were compared with the histopathological results from 16 intraductal biopsies, 3 excisional biopsies, 24 microdochectomies and 12 mastectomies.

Results

Contrast enhanced MR imaging demonstrated all malignant lesions including ductal carcinomain situ (DCIS). Four cases of DCIS were not visualized by ultrasonography and three malignant lesions were missed by galactography. In the MR study, segmental clumped enhancement (positive predictive value = 100%), and focal mass with smooth border (negative predictive value = 87.5%) were the statistically significant predictive factors.

Conclusions

Among the three modalities, contrast-enhanced three-dimensional MR imaging demonstrated the location and distribution of the lesions most clearly, especially in cases of ductal carcinomain situ. It has the potential to be a useful diagnostic tool for patients with nipple discharge.

Key words

MRI Ultrasonography Galactography, Nipple discharge 

Abbreviations

MR

Magnetic resonance

US

Ultrasonography

DCIS

Ductal carcinoma insitu

IDC

Invasive ductal carcinoma

SPGR

Spoiled gradient-recalled echo

MIP

Maximum intensity projection

MPR

Multiplanar reconstruction

MLO

Mediolateral oblique

CC

Craniocaudal

BI-RADS

Breast Imaging Reporting and Data System

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Copyright information

© The Japanese Breast Cancer Society 2003

Authors and Affiliations

  • Hiroshi Nakahara
    • 1
  • Kiyoshi Namba
    • 2
  • Ryoji Watanabe
    • 2
  • Hidemi Furusawa
    • 2
  • Takafumi Matsu
    • 2
  • Futoshi Akiyama
    • 3
  • Goi Sakamoto
    • 3
  • Snozo Tamura
    • 1
  1. 1.Department of RadiologyMiyazaki Medical CollegeMiyazakiJapan
  2. 2.Breastopia Namba HospitalBreastopia Medical CorporationJapan
  3. 3.Department of Breast PathologyCancer Institute HospitalJapan

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