Breast Cancer

, Volume 10, Issue 1, pp 21–27

Bone metabolic markers in bisphosphonate therapy for skeletal metastases in patients with breast cancer

Review Article

DOI: 10.1007/BF02967621

Cite this article as:
Koizumi, M., Takahashi, S. & Ogata, E. Breast Cancer (2003) 10: 21. doi:10.1007/BF02967621

Abstract

The use of bisphosphonates for skeletal metastasis of breast cancer is now well established. Although clinical judgement for treating skeletal metastasis is based on symptoms and imaging studies, accurate or quantitative means are few. Various bone metabolic markers have been developed and these were evaluated in patients with metastasis to bone. Bone metabolic markers, especially resorption markers, have been shown to be a good tool for the monitoring the response to therapy for skeletal metastasis. This is also true for bisphosphonate treatment for skeletal metastasis. Bone metabolic markers are produced by different mechanisms. There are some different classes of resorption markers; tartrate-resistant acid phosphatase (TRAP) is secreted by osteoclast, N- and C-terminal cross-linking telopeptide of type I collagen (NTx and CTx) are the degradation the products of type I collagen, mainly produced by cathepsin K, and pyridinoline cross-linked carboxyl-terminal telopeptides of type I collagen (ICTP) is also a degradation product of type I collagen, by matrix metalloproteases. Even though bone resorption markers are a good tool to monitor response to bisphosphonate therapy, there remains the question of which class of bone resorption markers is best suited to the task.

Key words

Bone metabolic marker Skeletal metastasis Bisphosphonate 

Abbreviations

Al-p

Alkaline phosphatase

BAI-p

Bone specific alkaline phosphatase

BGP

Bone gla protein also called osteocalcin

BSP

Bone sialoprotein

Cat K

Cathepsin K

CTx

C-terminal cross-linking telopeptide of type I collagen

DPD

Deoxy-pyridinoline

fDPD

Free deoxy-pyridinoline

ICTP

Pyridinoline cross-linked carboxyl-terminal telopeptides of type I collagen

MMP

Matrix metalloprotease

MRI

Magnetic resonance imaging

NTx

N-terminal cross-linking telopeptide of type I collagen

OC

Osteocalcin

PICP

Carboxy-terminal propeptide of type I procollagen

PINP

amino-terminal propeptide of type I procollagen

PYP

Pyridinolone

TRAP

Tartrate resistant acid pnosphatase

TRAP 5b

Tartrate resistant acid phosphatase 5b

Copyright information

© The Japanese Breast Cancer Society 2003

Authors and Affiliations

  • Mitsuru Koizumi
    • 1
  • Shunji Takahashi
    • 2
  • Etsuro Ogata
    • 3
  1. 1.Departments of Nuclear MedicineCancer Institute HospitalJapan
  2. 2.Departments of Medical OncologyCancer Institute HospitalJapan
  3. 3.Departments of Internal MedicineCancer Institute HospitalJapan

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