Breast Cancer

, Volume 5, Issue 3, pp 301–307 | Cite as

Histologic examination of two cases of cystosarcoma phylloaes with pulmonary metastases

  • Tetsuro Kobayashi
  • Hideki Asakawa
  • Haruki Fukuda
  • Hiromu Andachi
  • Yoshifumi Komoike
  • Yoshiaki Nakano
  • Yasuhiro Tamaki
  • Morito Monden
Case Report
Received:
Accepted:
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Abstract

Background

Cystosarcoma phyllodes (CP) is a rare neoplasm of the breast. Many studies of the histology of CP have been reported. However, few reports have included an evaluation of the histologic appearance of pulmonary metastases, or the change in histologic grade as a function of time in patients with recurrent tumors.

Methods

We treated two patients with pulmonary metastases, CP from 1973 to 1995. One patient died of respiratory failure. The other underwent six operations for CP. We evaluated the histologic characteristics of these metastases and changes in the histologic grade of recurrent tumors.

Results

The primary lesions in these two cases were typical high-grade malignant tumors. Case 1 had multiple pulmonary metastases and histologic findings indicated typical malignant CP. Case 2 had a solitary pulmonary metastasis and histologic findings showed low-grade malignant CP, which could be resected. The first patient died of respiratory failure ten months after surgery. The second had no further pulmonary metastases although she had frequent local recurrences, and the histologic features of these tumors became progressively worse.

Conclusion

We suggest that patients with malignant CP be followed closely and that when pulmonary metastases are detected, they should be resected if possible, because pulmonary metastatic tumors may represent lower-grade malignant CP.

Key words

Cystosarcoma phyllodes Pulmonary metastases Malignant grade Recurrence 

Abbreviations

CP

Cystosarcoma phyllodes

H&E

Hematoxylin and eosin

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Copyright information

© The Japanese Breast Cancer Society 1998

Authors and Affiliations

  • Tetsuro Kobayashi
    • 1
  • Hideki Asakawa
    • 2
  • Haruki Fukuda
    • 3
  • Hiromu Andachi
    • 4
  • Yoshifumi Komoike
    • 1
  • Yoshiaki Nakano
    • 1
  • Yasuhiro Tamaki
    • 1
  • Morito Monden
    • 1
  1. 1.Department of SurgeryOsaka National HospitalOsakaJapan
  2. 2.The second Department of Internal MedicineOsaka University Medical SchoolJapan
  3. 3.Department of PathologyHabikino Prefectural HospitalJapan
  4. 4.Department of PathologyMatsushita Memorial HospitalJapan

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