Breast Cancer

, Volume 7, Issue 4, pp 341–344 | Cite as

Treatment of noninvasive carcinoma: Fifteen-Year results at the National Cancer Center Hospital in Tokyo

  • Sadako Akashi-Tanaka
  • Takashi Fukutomi
  • Takeshi Nanasawa
  • Kaneyuki Matsuo
  • Tadashi Hasegawa
  • Hitoshi Tsuda
Panel Discussion II


The introduction of screening mammography (MMG) will lead to increased detection of preclinical early breast cancer in Japan. It has become more important to understand the nature of these lesions. We tried to elucidate the long term prognosis and clinical and pathological characteristics of noninvasive cancers.

A total of 336 (5.4%) ductal carcinomain situ (DCIS) and 32 (0.5%) lobular carcinomain situ (LCIS) were diagnosed in 6 277 breast carcinomas at the National Cancer Center Hospital from 1962 to 1995. Most (80%) LCIS occurred in premenopausal women. LCIS has significantly higher bilaterality than that of DCIS. Local recurrence occurred in approximately 10% of patients after breast conserving surgery for DCIS and LCIS. Four patients died of breast carcinoma, which were initially diagnosed as noninfiltrating carcinoma. The 15-year cause specific survival rates of patients with DCIS and LCIS were 98.5 % and 100 %, respectively.

Key words

Breast cancer Ductal carcinomain situ Lobular carcinomain situ Long term result 





Ductal carcinomain situ


Lobular carcinomain situ


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Schwartz G, Solin L, Olivotto I,et al: The consensus conference on the treatment of in situ ductal carcinoma of the breast, April 22–25,1999.Hum Pathol 31:131–139, 2000.PubMedCrossRefGoogle Scholar
  2. 2).
    Frykberg E, Bland K:In situ breast carcinoma.Advances in Surgery 26:29–72, 1993.PubMedGoogle Scholar
  3. 3).
    Fisher B, Dignam J, Wolmark N,et al: Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. J Clin Oncol 16:441–452, 1998.PubMedGoogle Scholar
  4. 4).
    Solin LJ, Recht A, Fourquet A,et al: Ten-year results of breast-conserving surgery and definitive irradiation for intraductal carcinoma (ductal carcinoma in situ) of the breast. Cancer 68:2337–2344, 1991.PubMedCrossRefGoogle Scholar
  5. 5).
    Andersen J: Lobular carcinomain situ of the breast: an approach to rational treatment.Cancer 39:2597–2602, 1977.PubMedCrossRefGoogle Scholar
  6. 6).
    Haagensen CD, Bodian C, Haagensen DE: Lobular neoplasia (lobular carcinomain situ) In: Haagensen CD, Bodian C, Haagensen DE eds, Breast carcinoma: risk and detection. WB Saunders, Philadelphia, pp238–292, 1981.Google Scholar
  7. 7).
    Page DL, Kidd TE, Dupont W,et al: Lobular neoplasia of the breast: higher risk for subsequent invasive cancer predicted by more extensive disease.Hum Pathol 22:1232–1239, 1991.PubMedCrossRefGoogle Scholar
  8. 8).
    Wheeler JE, Enterline HT, Roseman JM,et al: Lobular carcinomain situ of the breast: Long-term followup.Cancer 34:554–563, 1974.PubMedCrossRefGoogle Scholar
  9. 9).
    Rosen P, Kosloff C, Lieberman P,et al: Lobular carcinomain situ of the breast. Detailed analysis of 99 patients with average follow-up of 24 years.Am J Surg Pathol 2:225–251, 1978.PubMedCrossRefGoogle Scholar
  10. 10).
    Simmons R, Osborne M: The evaluation of high risk and pre-invasive breast lesions and the decision process for follow up and surgical intervention.Surg Oncol 8:55–65, 1999PubMedCrossRefGoogle Scholar
  11. 11).
    Styblo TM, Wood WC: The management of ductal and lobular breast cancer.Surg Oncol 8:67–75, 1999PubMedCrossRefGoogle Scholar
  12. 12).
    Morrow M, Schnitt S, Harris J: Microinvasive carcinoma. In: Harris J, Lippman M, Morrow M, Osborne C, eds, Diseases of the breast, Lippincott Williams & Wilkins, Philadelphia, pp389–390, 1999.Google Scholar
  13. 13).
    Akashi-Tanaka S, Fukutomi T, Miyakawa H,et al: Constrast-enhanced computed tomography detection of occult breast cancer presenting as axillary masses.Breast Cancer Res Treat 55:97–101, 1999.PubMedCrossRefGoogle Scholar
  14. 14).
    Fujii K, Fukutomi T, Tsuda H,et al: Microinvasive breast carcinoma with extensive involvement of level III axillary lymph nodes: a case report.Jpn J Clin Oncol 28:47–49, 1998.PubMedCrossRefGoogle Scholar
  15. 15).
    Silverstein M: Van Nuys experience by treatment. In: Silverstein M, ed, Ductal carcinomain situ of the breast. Williams & Wilkins, Baltimore, p443, 1997.Google Scholar

Copyright information

© The Japanese Breast Cancer Society 2000

Authors and Affiliations

  • Sadako Akashi-Tanaka
    • 1
  • Takashi Fukutomi
    • 1
  • Takeshi Nanasawa
    • 1
  • Kaneyuki Matsuo
    • 1
  • Tadashi Hasegawa
    • 2
  • Hitoshi Tsuda
    • 2
  1. 1.Division of Breast SurgeryNational Cancer Center HospitalJapan
  2. 2.Pathology DivisionNational Cancer Center Research InstituteJapan

Personalised recommendations