Comprehensive Therapy

, Volume 25, Issue 11–12, pp 479–491 | Cite as

Breast implants and fibromyalgia

  • Eric Siceloff
  • Greg Blasko
  • Bruce Rothschild
Original Article


The frequency of major rheumatologic diseases among individuals with breast implants was indistinguishable from fibromyalgia controls. Fibromyalgia-like symptoms among 183 individuals with silicone breast implants were almost indistinguishable from those found in 100 consecutive women with unrelated fibromyalgia.


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  1. 1.
    Bridges AJ, Conley C, Wang G, et al. A clinical and immunologic evalaution of women with silicone breast implants and symptoms of rheumatic disease.Ann Int Med. 1993;118:929–936.PubMedGoogle Scholar
  2. 2.
    Koeger AC, Bourgeois P. Systemic manifestations after silicone breast implants.Rev Rheum. 1993;60:120–126.Google Scholar
  3. 3.
    Varga J, Schumacher HR, Jimenez SA. Systemic sclerosis after augmentation mammoplasty with silicone implants.Ann Intern Med. 1989;111;377–383.PubMedGoogle Scholar
  4. 4.
    Weisman MH, Vecchione TR, Albert D, et al. Connectivetissue disease following breast augmentation: a primary test of the human adjuvant disease hypothesis.Am J Med. 1988;82:626–630.Google Scholar
  5. 5.
    Silverman BG, Brown SL, Bright RA, et al. Reported complications of silicone breast implants: an epidemiologic review.Ann Intern Med. 1996;124:744–756.PubMedGoogle Scholar
  6. 6.
    Blackburn WD Jr, Everson MP. Silicone-associated rheumatic disease: an unsupported myth.Plast Reconstr Surg. 1997;99:1362–1367.PubMedCrossRefGoogle Scholar
  7. 7.
    Cook LS, Daling JR, Voigt LF, et al. Characteristics of women with and without breast augmentation.JAMA. 1997;277:1612–1617.PubMedCrossRefGoogle Scholar
  8. 8.
    Cuellar ML, Gluck O, Molina JF, et al. Silicone breast implant-associated musculoskeletal manifestations.Clin Rheumatol. 1995;14:667–672.PubMedCrossRefGoogle Scholar
  9. 9.
    Deapen DM, Bernstein L, Brody GS. Are breast implants anticarcinogenic? a 14-year follow-up of the Los Angeles study.Plast Reconstr Surg. 1997;99:1346–1353.PubMedCrossRefGoogle Scholar
  10. 10.
    Del Junco DJ. More breast implant pros and cons: contractures and confounding: the controversy continues.JAMA. 1997;277:1643–1644.PubMedCrossRefGoogle Scholar
  11. 11.
    Gabriel SE, Woods JE, O’Fallon WM, et al. Complications leading to surgery after breast implantation.N Engl J Med. 1997;336:677–682.PubMedCrossRefGoogle Scholar
  12. 12.
    Noone RB. A review of the possible health implications of silicone breast implants.Cancer. 1997;79:1747–1756.PubMedCrossRefGoogle Scholar
  13. 13.
    Rothschild BM. Rheumatologic presentation and workup of silicone-exposed patients.Int J Occupat Med Toxicol. 1995;4:9–89.Google Scholar
  14. 14.
    Netscher DT, Sharma S, Thornby J, et al. Aesthetic outcome of breast implant removal in 85 consecutive patients.Plast Reconstr Surg. 1997;100:206–219.PubMedCrossRefGoogle Scholar
  15. 15.
    Goldberg EP, Widenhouse C, Marotta J, et al. Failure of silicone gel breast implants: analysis of literature data for 1652 explanted prostheses.Plast Reconstr Surg. 1997;100:281–284.PubMedGoogle Scholar
  16. 16.
    Cohen BE, Biggs TM, Cronin ED, et al. Assessment and longevity of the silicone gel breast implant.Plast Reconstr Surg. 1997;99:1597–1601.PubMedCrossRefGoogle Scholar
  17. 17.
    Rosenberg JT. Lessons from litigation over silicone breast implants: a call for activism by scientists.Science. 1997;276:1524–1525.CrossRefGoogle Scholar
  18. 18.
    Van Nunen SA, Gatenby PA, Basten A. Post-mammoplasty connective tissue disease.Arthritis Rheum. 1982;6:694–697.CrossRefGoogle Scholar
  19. 19.
    Fenske TK, Davis P, Aaron SL. Human adjuvant disease revisited: a review of eleven post-augmentation mammoplasty patients.Clin Exp Rheumatol. 1994;12:477–481.PubMedGoogle Scholar
  20. 20.
    Gedalia A, Cuellar ML, Espinoza LR. Skin rash and anti-Ro/SS-A antibodies in an infant from a mother with silicone breast implants.Clin Exp Rheumatol. 1995;13:521–523.PubMedGoogle Scholar
  21. 21.
    Goldman JA, Greenblatt J, Joines R, et al. Breast implants, rheumatoid arthritis, and connective tissue disease in a clinical practice.J Clin Epidemiol. 1995;48:571–582.PubMedCrossRefGoogle Scholar
  22. 22.
    Giltay EJ, Bernelot Moens HJ, Riley RH, et al. Silicone breast prostheses and rheumatic symptoms: a retrospective followup study.Ann Rheumatic Dis. 1994;53:194–196.CrossRefGoogle Scholar
  23. 23.
    Gabriel SE, O’Fallon WM, Kurland LT, et al. Risk of connective-tissue diseases and other disorders after breast implantation.N Engl J Med. 1994;330:1697–1702.PubMedCrossRefGoogle Scholar
  24. 24.
    Bostwick J III. Breast reconstruction following mastectomy.CA Cancer J Clin. 1995;45:289–304.PubMedCrossRefGoogle Scholar
  25. 25.
    Edworthy SM, Martin L, Barr SG, et al. A clinical study of the relationship between silicone breast implants and connective tissue disease.J Rheumatol. 1998;25:254–260.PubMedGoogle Scholar
  26. 26.
    Hochberg MC, Perlmutter DL, White B, et al. The association of augmentation mammoplasty with systemic sclerosis: results from a multi-center case-control study.Arthritis Rheum. 1994;37:S369.Google Scholar
  27. 27.
    Englert HJ, Brooks P. Scleroderma and augmentation mammoplasty—a causal relationship?Aust N Z J Med. 1994;24:74–80.PubMedGoogle Scholar
  28. 28.
    Hennekens CH, Lee I-M, Cook NR, et al. Self-reported breast implants and connective-tissue diseases in female health professionals: a retrospective study.JAMA. 1996;275:616–621.PubMedCrossRefGoogle Scholar
  29. 29.
    Hochberg MC, Perlmutter DL, Medsger TA, et al. The prevalence of self-reported physician-diagnosed systemic lupus erythematosus in the United States.Lupus. 1995;4:454–456.PubMedCrossRefGoogle Scholar
  30. 30.
    Goldenberg DL. Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.Curr Opin Rheumatol. 1991;3:247–258.PubMedCrossRefGoogle Scholar
  31. 31.
    Shoaib BO, Patten BM, Calkins DS. Adjuvant breast disease: an evaluation of 100 symptomatic women with breast implants or silicone fluid injections.Keio J Med. 1994;43:79–87.PubMedGoogle Scholar
  32. 32.
    Goldenberg DL. Psychological symptoms and psychiatric diagnosis in patients with fibromyalgia.J Rheumatol. 1989;6:S127-S130.Google Scholar
  33. 33.
    Merskey H. Physical and psychological considerations in the classification of fibromyalgia.J Rheumatol. 1989;16:15S-22S.Google Scholar
  34. 34.
    Dailey PA, Bishop GD, Russell IJ, et al. Psychological stress and the fibrositis/fibromyalgia syndrome.J Rheumatol. 1990;17:1380–1385.PubMedGoogle Scholar
  35. 35.
    Modofsky H, Tullis C, Lue FA, et al. Sleep-related myoclonus in rheumatic pain modulation disorder (fibrositis syndrome) and in excessive daytime somnolence.Psychosomat Med. 1984;11:145–151.Google Scholar
  36. 36.
    Breast Implants Products Liability Litigation. MDL no. 926. United States District Court — Northern District of Albama. 1997.Google Scholar
  37. 37.
    Schumacher HR Jr.Primer on the Rheumatic Diseases. 10th ed. Atlanta, GA: Arthritis Foundation; 1993.Google Scholar
  38. 38.
    Wolfe F, Simons DG, Fricton J, et al. The fibromyalgia and myofascial pain syndromes: a preliminary study of tender points and trigger points in persons with fibromyalgia, myofascial pain syndrome and no disease.J Rheumatol. 1992;19:944–951.PubMedGoogle Scholar
  39. 39.
    Rosenberg NL. The neuromythology of silicone breast implants.Neurology. 1996;46:308–314.PubMedGoogle Scholar
  40. 40.
    Eberhardt KB, Fex E. Functional impairment and disability in early rheumatoid arthritis.J Rheumatol. 1995;22:1037–1042.PubMedGoogle Scholar
  41. 41.
    Wolfe F, Kleinheksel SM, Cathey MA, et al. The clinical value of the Stanford Health Assessment Questionnaire functional disability index in patients with rheumatoid arthritis.J Rheumatol. 1988;15:1480–1488.PubMedGoogle Scholar
  42. 42.
    Berkson J. The statistical study of association between smoking and lung cancer.Proc Mayo Clin. 1955;30:319–348.Google Scholar
  43. 43.
    Brown GW. Berkson fallacy revisited: spurious conclusions from patient surveys.Am J Dis Child. 1976;130:56–60.PubMedGoogle Scholar
  44. 44.
    Wolfe F, Cathey MA, Kleinheksel SM, et al. Psychological status in primary fibrositis and fibrositis associated with rheumatoid arthritis.J Rheumatol. 1984;11:500–506.PubMedGoogle Scholar

Copyright information

© the American Society of Contemporary Medicine and Surgery 1999

Authors and Affiliations

  • Eric Siceloff
    • 1
  • Greg Blasko
    • 1
  • Bruce Rothschild
    • 2
  1. 1.Foot & Ankle CenterYoungstown Osteopathic HospitalYoungstown
  2. 2.The Arthritis Center of Northeast OhioYoungstown

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