Irish Journal of Medical Science

, Volume 162, Issue 3, pp 95–97 | Cite as

Glandular differentiation in cardiac myxomata

  • C. M. Thornton
  • M. Y. Walsh


We present a case of cardiac myxoma associated with Carney’s complex in which histological examination revealed numerous well formed glandular structures at the base of the lesion. Immunoperoxidase studies showed these glands to be epithelial-like with positive staining for EMA, CEA and CAM 5.2. Mucin stains were also positive. The presence of these gland-like structures within a cardiac myxoma, unless recognised as part of the tumour, may lead to the erroneous diagnosis of secondary adenocarcinoma. We reviewed eighteen further cardiac myxomata of which two were associated with Carney’s complex. Of these eighteen tumours only one, not associated with Carney’s complex, contained glandular structures and these were poorly formed.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Wold, L. E., Lie, J. T. Cardiac myxoma: A clinicopathological profile. Am. J. Pathol. 1980: 101, 219–240.PubMedGoogle Scholar
  2. 2.
    Lie, J. T. The identity and histogenesis of cardiac myxoma, a controversy put to rest. Arch. Pathol. Lab. Med. 1989: 113, 724–726.PubMedGoogle Scholar
  3. 3.
    Pritchard, R. W. Tumours of the heart: Review of the subject and report of one hundred and fifty cases. Arch. Pathol. Lab. Med. 1951: 51, 98–128.Google Scholar
  4. 4.
    Griffiths, G. C. A review of primary tumours of the heart. Prog. Cardiovasc. 1965: Disc; 7, 465–479.CrossRefGoogle Scholar
  5. 5.
    Carney, J. A., Gordon, H., Carpenter, P. al. The complex of myxomas, spotty pigmentation and endocrine overactivity. Medicine 1985: 64(4), 270–283.PubMedCrossRefGoogle Scholar
  6. 6.
    Anderson, W. A. D., Dmytryk, E. T. Primary tumor of the heart containing epithelium-like elements. Am. J. Path. 1946: 22, 337–349.Google Scholar
  7. 7.
    Johansson, L. Histogenesis of cardiac myxomas. Arch. Pathol. Lab. Med. 1989: 113, 735–741.PubMedGoogle Scholar
  8. 8.
    Abenoza, P., Sibley, R. K. Cardiac myxoma with gland-like structures. Arch. Pathol. Lab. Med. 1986: 110, 736–739.PubMedGoogle Scholar
  9. 9.
    Goldman, B. I., Frydman, C., Harpaz, al. Glandular cardiac myxomas. Cancer 1987: 59, 1767–1775.PubMedCrossRefGoogle Scholar
  10. 10.
    Thornton, C. M., Handley, J., Bingham, E. A., Walsh, M. Y. Psammomatous melanotic schwannoma arising in the dermis in a patient with Carney’s complex. Histopathology 1992: 20, 71–73.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1993

Authors and Affiliations

  • C. M. Thornton
    • 1
  • M. Y. Walsh
    • 1
  1. 1.Department of PathologyInstitute of Pathology, Royal Victoria HospitalBelfastUnited Kingdom

Personalised recommendations