Journal of Biosciences

, Volume 24, Issue 2, pp 143–152 | Cite as

The control of tuberculosis: a continuous game of snakes and ladders

  • T. Ramakrishnan
  • P. Chandrasekhar


Tuberculosis Isoniazid Leprosy Mycolic Acid Avirulent Strain 
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  1. Anilkumar G, Chauhan M M and Ajitkumar P 1998 Cloning and expression of the gene coding for FtsH protease from Mycobacterium TB H37Rv;Gene 214 7–11PubMedCrossRefGoogle Scholar
  2. Bloom B R (ed.) 1994TB: Pathogenesis, Protection and Control (Washington DC: Am. Soc. Microbiol.)Google Scholar
  3. Chandrasekhar P 1988 Primary health care and TB programme;NTI Newslett. 24 1–23Google Scholar
  4. Chauhan M M 1997 Reliability and applicability of serological tests in the diagnosis of TB;NTI Bull. 33 56–61Google Scholar
  5. Cole S T, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon S V, Eiglmeier K, Gas S, Barry III C E, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail M A, Rajandream M-A, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston J E, Taylor K, Whitehead S. and Barell B G 1998 Deciphering the biology of Mycobacterium TB from the complete gene sequence;Nature (London) 393 537–544; 396 190–198CrossRefGoogle Scholar
  6. Gayathri Devi B, Shaila M S, Ramakrishnan T and Gopinathan K P 1975 Purification and properties of peroxidase in Mycobacterium TB H37Rv and its possible role in the mechanism of action isonicotinic acid hydrazide;Biochem. J. 149 187–197Google Scholar
  7. Heym B 1999 The molecular basis of isoniazid resistance in Mycobacterium TB; inIndo-French Symp. Multiple Drug Resistance and Emerging Diseases (New Delhi: Indian National Science Academy) Abstracts, p 10Google Scholar
  8. Koch R 1932 Die Aetiologie der Tuberkulose;Am. Rev. Tuberc. 25 282–323 (Translated by Pruner B and Pinnor from the original 1882 article)Google Scholar
  9. Leach A, Shelby-James T, Mayo M, Gratten M and Mathews J 1995 Report of a multidrug resistant clone ofSteptococcus pneumoniae in aboriginal infants in the Northern Territory;Commun. Dis. Intelligence 19 134–137Google Scholar
  10. Madhusudan K, Ramesh V and Nagaraja V 1994 Cloning and sequence analysis of DNA gyrase genes from Mycobacterium TB;Curr. Sci. 66 664–667Google Scholar
  11. Madhusudan K and Nagaraja V 1996 Alignment and phylogenetic analysis of type II DNA topoisomerases;J. Biosci. 21 613–629CrossRefGoogle Scholar
  12. Mehta Gita 1997Snakes and Ladders (London: Minerva)Google Scholar
  13. Minnikin D E 1982 Lipids: Complex Lipids, their chemistry, biosynthesis and roles; inThe Biology of Mycobacteria (eds) C Ratledge and J Stanford (London: Academic Press) vol 1 pp 95–184Google Scholar
  14. Murray C J L and Salomon J A 1998 Modeling the impact of TB control strategies;Proc. Natl. Acad. Sci. USA 95 13881–13886PubMedCrossRefGoogle Scholar
  15. Ramakrishnan T 1983 Twenty five years of research on tuberculosis at the Indian Institute of Science, Bangalore;Curr. Sci. 52 398–402Google Scholar
  16. Ratledge C and Stanford J (eds) 1982The biology of mycobacteria vol. 1 (London, New York: Academic Press)Google Scholar
  17. Rekha Prabhu, Ramananda Rao G, Jamaluddin M and Ramakrishnan T 1986 N-[2-naphthyl]-glycine hydrazide, a potent inhibitor of DNA-dependent RNA polymerase of Mycobacterium TB H37Rv;J. Biosci. 10 163–166CrossRefGoogle Scholar
  18. Riley M and Labadan B 1996 inEscherichia coli and Salmonella (ed) F C Neidhardt (Washington DC: Am. Soc. Microbiol.) pp 2118–2202Google Scholar
  19. Rosen H, Richard H, Silver L, Kropp H, Dorso K, Kohler J, Sundelof J G, Huber J, Hammond G G, Jackson J J, Gill C J, Thompson R, Pelak B A, Epstein-Toney J H, Lankas G, Wilkening R R, Wildonger K J, Blizzard T A, DiNinno F P, Ratcliffe R W, Heck J V, Kozarick J W, and Hammond M L 1999 Reduced immunotoxicity and preservation of antibacterial activity in a released side-chain carbapem antibiotic;Science 283 703–706PubMedCrossRefGoogle Scholar
  20. Rozworski D A, Grant G A, Barton D H R, Jacobs W R Jr, Sachettini J C 1998 Modification of NADH of the isoniazid target (Inh A) from Mycobacterium TB;Science 279 98–102CrossRefGoogle Scholar
  21. Russell B 1969 The Autobiography of Bertrand Russell 1944–969 (Simon and Schuster) p 16Google Scholar
  22. Sengupta U 1999 Diagnosis of leprosy in India - Relevance and Perspectives; inIndo-French Symp. Multiple Drug Resistance and Emerging Diseases (New Delhi: Indian National Science Academy) AbstractsGoogle Scholar
  23. Seshadri R, Suryanarayana Murthy P and Venkitasubramanian T A 1976 Isocitrate lyase in mycobacteria;Indian J. Biochem. Biophys. 13 95–96PubMedGoogle Scholar
  24. Suryanarayana Murthy P S, Sirsi M and Ramakrishnan T 1973 Effect of age on the enzymes of tricarboxylic acid cycle and related enzymes in Mycobacterium TB H37Rv;Am. Rev. Resp. Dis. 108 689–690Google Scholar
  25. Takayama K, Antony E L and David H L 1974 Restoration of mycolate synthetase activity in Mycobacterium TB exposed to isoniazid;Am. Rev. Resp. Dis. 110 43–48PubMedGoogle Scholar
  26. Uplekar M W, Javekar S K and Parende S D 1996 TB management in private practice and its implications;Indian J. Tuberc. 43 19–22Google Scholar
  27. Wang J C 1985 DNA topoisomerases;Annu. Rev. Biochem. 54 665–697PubMedCrossRefGoogle Scholar
  28. Waksman S A 1949 Streptomycin - Nature and Practical Applications (London: Bailliere, Tindall and Cox)Google Scholar
  29. Wayne L G and Lin K Y 1982 Glyoxylate metabolism and adaptation of Mycobacterium TB to survival under anaerobic conditions;Infect. Immun. 24 363–370Google Scholar
  30. Wilkinson E 1914 Notes on the prevalence of TB in India;Proc. R. Soc. Med. 8 195–225Google Scholar
  31. Winder F G and Collins P B 1970 Inhibition by isoniazid of synthesis of mycolic acids in Mycobacterium TB;J. Gen. Microbiol. 63 41–48PubMedGoogle Scholar
  32. Winder F G 1982 Mode of action of the antimycobacterial agents and associated aspects of the molecular biology of the Mycobacteria; inThe Biology of the Mycobacteria (eds) C Ratledge and J Stanford (London: Academic Press) vol 1, pp 353–438Google Scholar
  33. World Health Organization 1996 Managing TB at national level. Global TB programme; (Geneva: WHO) pp 203–210Google Scholar
  34. World Health Organization Global TB Programme 1997 WHO Report on TB (Geneva: WHO)Google Scholar

Copyright information

© Indian Academy of Sciences 1999

Authors and Affiliations

  1. 1.Department of Microbiology and Cell BiologyIndian Institute of ScienceBangaloreIndia
  2. 2.National Tuberculosis InstituteBangaloreIndia

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