Herpes simplex encephalitis and sarcoidosis
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Fatal herpes simplex encephalitis occurring in a patient with sarcoidosis is described. Ultrastructural study of brain tissue revealed the presence of herpesvirus particles. The association of these 2 diseases has not been recorded before. The encephalitis in this case probably represents an opportunistic viral infection in the face of depressed cellular immunity. Progressive multifocal leukoencephalopathy, a disease of putative viral aetiology, is known to occur in patients with sarcoidosis and it is suggested that this case represents a similar pathogenetic association.
KeywordsHerpes Simplex Encephalitis Sarcoidosis Progressive Multifocal Leukoencephalopathy Herpes Simplex Encephalitis
- Illis, L. S. 1975. Treatment of viral encephalitis.In: Viral Diseases of the Central Nervous System. Ed. L. S. Illis. London. Bailliere, Tindall. p. 90.Google Scholar
- Korsager, B., Spencer, E. S. and Mordhorst, C. H. 1975. Herpesvirus hominis infections in renal transplant recipients. Scand J. Infec. Dis. 7, 11.Google Scholar
- Mathews, T., Wisotzkey, H. and Moossy, J. 1976. Multiple central nervous system infections in progressive multifocal leukoencephalopathy. Neurology (Minneap.) 26, 9.Google Scholar
- Rand, K. H., Rasmussen, L. E., Pollard, R. B., Arvin, A. and Merigan, T. C. 1976. Cellular immunity and herpesvirus infections in cardiac transplant patients. New Engl. J. Med. 296, 1372.Google Scholar