Studies on six patients with isolated hypogonadotropic hypogonadism — The response to a short course of pulsatile LHRH

  • G. C. Hawthorne
  • B. Sheridan
  • H. Leslie
  • A. B. Atkinson
Article
  • 15 Downloads

Abstract

SIX patients with idiopathic hypogonadotropic hypogonadism, five males and one female, aged 20–26 years, were studied. All therapy with either testos terone or oestrogen was stopped for at least two months prior to the study. Basal levels of serum LH, FSH, oestradiol and testosterone were low and the response to 100 ug LHRH intravenously was vari able, ranging from a flat response to a normal response. Pulsatile doses of LHRH 25 ng/kg were administered sub cutaneously every two hours over a 72 hour period. The serum levels of testos terone and oestradiol remained at the previous low values but the levels of LH and FSH rose significantly in all patients. The response to 100 ug LHRH intravenously immediately after this treatment was unchanged. If there is not a consistent rise in LH in the early days after initiation of LHRH pulsatile therapy, changes to the dose and/or route of administration should be made.

Keywords

Testosterone Luteinizing Hormone Hypogonadism Luteinizing Hormone Release Hormone Situs Inversus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. C. Hawthorne
    • 1
  • B. Sheridan
    • 1
  • H. Leslie
    • 1
  • A. B. Atkinson
    • 1
  1. 1.Metabolic Unit and Regional Endocrine LaboratoryRoyal Victoria HospitalBelfast

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