Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease
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Adhesion molecules mediate the extravasation of leukocytes and their accumulation in inflamed tissues. In the present study, serum concentrations of the selectin (sP- and sE-selectin) and immunoglobulin supergene family (sICAM-1 and sVCAM-1) of adhesion molecules were measured in 93 patients with inflammatory bowel disease (Crohn's disease,n=65; ulcerative colitis,n=28) and 58 age-matched normal controls. sP-selectin serum concentrations (mean ±SEM ng/ml) of patients with Crohn's disease (399 ±33 ng/ml) and ulcerative colitis (385 ± 42 ng/ml) were increased (P=0.0067 andP=0.0193, respectively) compared to controls (251±33 ng/ml). In contrast, E-selectin serum levels of patients with Crohn's disease (58±5 ng/ml) and ulcerative colitis (64±12 ng/ml) were not significantly higher than those of controls (53±5 ng/ml). sICAM-1 serum concentrations of patients with Crohn's disease (420±19 ng/ml) and those with ulcerative colitis (375±40 ng/ml) were elevated (P=0.0001 andP=0.0473, respectively) compared to controls (197±8 ng/ml). Further, sVCAM-1 levels of patients with Crohn's disease (664±43 ng/ml) and ulcerative colitis (963±162 ng/ml) were increased (P=0.0222 andP=0.0121, respectively) compared to controls (510±31 ng/ml). With few exceptions, serum levels of soluble adhesion molecules were not significantly correlated to disease activity indices or disease localization. Elevated circulating selectin and immunoglobulin supergene type adhesion molecules may compete with membrane-bound forms for their cognate ligands and thereby limit the rolling and stable adhesion of leukocytes.