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Virchows Archiv B

, 43:43 | Cite as

Immune suppression and histophysiology of the immune response

I. Cortisone acetate and lymphoid cell migration
  • A. A. Van den Broek
  • F. J. Keuning
  • R. Soeharto
  • N. Prop
Article

Summary

Seven daily intramuscular (im) injections of cortisone acetate (25 mg/Kg b.w.) given to rats or rabbits produced, (i) a pronounced reduction in the numbers of small lymphocytes in thymus-independent areas, (ii) atrophy of the thymic cortex, (iii) atrophy of germinal centres and (iv) a consequent depressed production of germinal centre-derived cells.

Lymphocyte depletion was not caused by cell lysis. Moreover cell traffic between peripheral lymphoid organs did not seem to be altered. A revival of the depressed germinal centres in cortisone-treated (inbred) rats could be achieved by a transfer of bone-marrow cell suspensions from normal, cortisone-treated or T-cell-deprived animals.

It was concluded that cortisone acetate arrests the migration of B-lymphocytes from the bone marrow to germinal centres in peripheral lymphoid organs, and that the accumulations of lymphoid cells in the bone marrow of cortison-treated animals might be composed of immature or mature T- and B-lymphocytes.

Key words

Corticosteroids Lymphoid cell migration Immune responsiveness Immune suppression 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • A. A. Van den Broek
    • 1
  • F. J. Keuning
    • 1
  • R. Soeharto
    • 1
  • N. Prop
    • 1
  1. 1.Department of HistologyEZ GroningenThe Netherlands

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