Biotechnology and Bioprocess Engineering

, Volume 7, Issue 5, pp 252–262 | Cite as

Production of arachidonic acid byMortierella fungi

  • Kenichi HigashiyamaEmail author
  • Shigeaki Fujikawa
  • Enoch Y. Park
  • Sakayu Shimizu


The growing interest in the application of arachidonic acid (ARA) in various fields of health and dietary requirements has elicited much attention on the industrial production of ARA-containing oil by the cultivation ofMortierella fungi. For the industrial production of ARA, various studies, such as isolation of a high-potential strain and optimization of culture conditions, have been conducted. Studies including the investigation of morphology are important because ARA is accumulated in the mycelia, and thus cultivation with high biomass concentration is essential for obtaining a high ARA yield. Combining the results derived from various studies, a high ARA yield was attained in an industrial fermentor. These ARA production techniques are applicable to the production of other polyunsaturated fatty acids (PUFAs), and will contribute to the improvement of fermentation technology especially in the field of fungal cultivation.


arachidonic acid Mortierella morphology industrial production 


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Copyright information

© The Korean Society for Biotechnology and Bioengineering 2002

Authors and Affiliations

  • Kenichi Higashiyama
    • 1
    Email author
  • Shigeaki Fujikawa
    • 1
  • Enoch Y. Park
    • 2
  • Sakayu Shimizu
    • 3
  1. 1.Institute for Fundamental ResearchSuntory LimitedOsakaJapan
  2. 2.Laboratory of Biotechnology, Department of Applied Biological Chemistry, Faculty of AgricultureShizuoka UniversityShizuokaJapan
  3. 3.Division of Applied Life Science, Graduate School of Agricultural SciencesKyoto UniversityKyotoJapan

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