Folia Microbiologica

, Volume 51, Issue 2, pp 67–85

Developments in herpes simplex virus vaccines: Old problems and new challenges

Review

DOI: 10.1007/BF02932160

Cite this article as:
Rajčáni, J. & Ďurmanová, V. Folia Microbiol (2006) 51: 67. doi:10.1007/BF02932160

Abstract

Vaccination has remained the best method for preventing virus spread. The herpes simplex virus (HSV) candidate vaccines tested till now were mostly purified subunit vaccines and/or recombinant envelope glycoproteins (such as gB and gD). In many experiments performed in mice, guinea pigs and rabbits, clear-cut protection against acute virus challenge was demonstrated along with the reduction of the extent of latency, when established in the immunized host. The immunotherapeutic effect of herpes vaccines seems less convincing. However, introduction of new adjuvants, which shift the cytokine production of helper T-cells toward stimulation of cytotoxic T-cells (TH1 type cytokine response), reveals a promising development. Mathematical analysis proved that overall prophylactic vaccination of seronegative women, even when eliciting 40–60 % antibody response only, would reduce the frequency of genital herpes within the vaccinated population. Even when partially effective, immunotherapeutic vaccination might represent a suitable alternative of chronic chemotherapy in recurrent labial and genital herpes.

Abbreviations

APC

antigen-presenting cell

CD

cluster of differentiation

CTL

cytotoxic T-lymphocyte (TC-lymphocyte)

CNS

central nervous system

DC

dendritic cell

E

early (mRNA expression)

gB, gC, gD, gE, gH

glycoproteins B-H

HLA

human leukocyte antigen

HSV

herpes simplex virus

Hve

herpes virus entry

i.c.

intracutaneous

IE

immediate early

i.m.

intramuscular

i.n.

intranasal

ICP

infected cell protein

IFN

interferon

IL

interleukin

LAT

latency-associated transcript

MHC

major histocompatibility complex

mRNA

messenger ribonucleic acid

p.i.

post-infection

PCR

polymerase chain reaction

PNS

peripheral nervous system

PVR

poliovirus receptor

RT-PCR

reversed transcription PCR

T-lymphocyte

thymus-dependent lymphocyte

TCR

T-cell receptor

TH

helper T-lymphocyte

TK

thymidine kinase

TNF

tumor necrosis factor

UL

unique long HSV DNA segment

US

unique short HSV DNA segment

vhs

virion host shutoff

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2006

Authors and Affiliations

  1. 1.Institute of VirologySlovak Academy of SciencesBratislavaSlovakia

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