Apoptosis and aging in mitochondrial morphology mutants ofS. cerevisiae
Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed.MDM30 andDNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast,YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes.FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.
green fluorescent protein(s)
polyribonucleotide nucleotidyltransferase (EC 220.127.116.11)
- Chen H.W., Rainey R.N., Balatoni C.E., Dawson D.W., Troke J.J., Wasiak S., Hong J.S., Mcbride H.M., Koehler C.M., Teitell M.A., French S.W.: Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis.Mol.Cell.Biol. 26, 8475–8487 (2006).PubMedCrossRefGoogle Scholar