Effect of 4-methyl-2-thiouracil on growth of leuconostoc mesenteroides
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Summary
The effect of the goitrogen 4-methyl-2-thiouracil in concentrations of 50—2,000 μg./10 ml. medium on growth ofL. mesenteroides was studied.
This substance has an inhibitory effect on growth ofL. mesenteroides only in media containing pyridoxine. Its effect is related to the concentration and to the presence of pyridoxine.
A high pyridoxine concentration (5.0 μg. /10 ml. medium) markedly reduces the effect of even 2,000 μg. 4-methyl-2-thiouracil/10 ml. medium.
Inhibition of growth ofL. mesenteroides by 4-methyl-2-thiouracil is abolished competitively by thymine, and non-competitively by thymidine and folie acid up to concentrations of 1,000 μg. 4-methyl-2-thiouracil/10 ml. medium.
Keywords
Adenine Thymidine Guanine Uracil PyridoxineЭффект от 4-метил-2-Thiouracil о ро с те Leuconostoc mesenteroides
Abstract
Эффект goitrogen 4-метил-2-Thiouracil конц е нтраций50—2,000 μg./10 ml.средни й п о росту L. mesenteroidesизучала сь. Это вещество, торм озящ ий эффект по рос ту L. mesenteroides то лько в средст ва массово й информации, содерж ащи е пиридоксин. Ее эффект связана с кон центрацие й и Присутствие пи ридо ксин. Высокая концентр ация пири доксин(5.0 μg./10 ml. medium)з аметно снижает эфф ект даже 2.000 μ g. 4-methyl-2-thiouracil/10 мл сре дой И нгибирование ростаL. mesenteroides 4-метил-2-thiouracil упр аздняется конкурсной основе thymine пу тем, а не на конкур сной п утем thymidine и folie кисло ты до кон центрации 1.000 μ g. 4-methyl-2-thiouracil/10 мл. ср еднесрочной.
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